Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway (Q26771260)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26729102 AND SRC:MED&resulttype=core&format=json

10 June 2020

Elisa Piscianz

2

1 reference

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10 June 2020

Claudia Loganes

3

1 reference

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10 June 2020

Liza Vecchi Brumatti

4

1 reference

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10 June 2020

Alessandra Knowles

5

1 reference

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10 June 2020

author name string

Sabrine Bilel

6

1 reference

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10 June 2020

Alberto Tommasini

7

1 reference

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10 June 2020

Roberta Bortul

8

1 reference

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10 June 2020

Marina Zweyer

9

1 reference

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International Journal of Molecular Sciences

10 June 2020

language of work or name

English

0 references

publication date

2016

0 references

30 December 2015

2 references

13 November 2019

19 November 2019

3 references

13 November 2019

19 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26729102 AND SRC:MED&resulttype=core&format=json

10 June 2020

volume

17

1 reference

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10 June 2020

issue

1

1 reference

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Creative Commons Attribution

10 June 2020

page(s)

47

0 references

copyright license

2 references

13 November 2019

19 November 2019

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

7 April 2017

1 reference

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

7 April 2017

1 reference

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Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase

7 April 2017

1 reference

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Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

7 April 2017

1 reference

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Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein

7 April 2017

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The NAIP/NLRC4 inflammasomes

7 April 2017

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Mitochondrial Redox Dysfunction and Environmental Exposures

7 April 2017

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Mitochondrial oxidative stress in aging and healthspan

7 April 2017

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Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

7 April 2017

1 reference

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Cholesterol, inflammation and innate immunity

7 April 2017

1 reference

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Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

7 April 2017

1 reference

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Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. [email protected]

7 April 2017

1 reference

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A role for mitochondria in NLRP3 inflammasome activation

7 April 2017

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Hyper-IgD syndrome/mevalonate kinase deficiency: what is new?

7 April 2017

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NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

7 April 2017

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Apoptosis: a review of programmed cell death

7 April 2017

1 reference

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Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

7 April 2017

1 reference

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The discovery and development of HMG-CoA reductase inhibitors

7 April 2017

1 reference

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Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium

7 April 2017

1 reference

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Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes

7 April 2017

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7 April 2017

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

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Regulation of the mevalonate pathway

7 April 2017

1 reference

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Autophagy in human health and disease

7 April 2017

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Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

7 April 2017

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The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects

7 April 2017

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The role of mitochondria in statin-induced myopathy

28 September 2017

1 reference

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Statin intolerance: diagnosis and remedies

28 September 2017

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Cardiovascular drug development: is it dead or just hibernating?

28 September 2017

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NLRP3 at the interface of metabolism and inflammation.

28 September 2017

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Mitochondria in autoinflammation: cause, mediator or bystander?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

28 September 2017

1 reference

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

28 September 2017

1 reference

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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

28 September 2017

1 reference

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Elevated Autophagy and Mitochondrial Dysfunction in the Smith-Lemli-Opitz Syndrome.

28 September 2017

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Adverse effects of statins - myths and reality

28 September 2017

1 reference

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Mitophagy and mitochondrial balance

28 September 2017

1 reference

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Keeping the immune system in check: a role for mitophagy

28 September 2017

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Unprenylated RhoA contributes to IL-1β hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity.

28 September 2017

1 reference

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Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

28 September 2017

1 reference

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Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

28 September 2017

1 reference

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A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse

28 September 2017

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Novel therapies for treating familial hypercholesterolemia

28 September 2017

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Mevalonate kinase deficiency and neuroinflammation: balance between apoptosis and pyroptosis

28 September 2017

1 reference

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Role of mitochondrial oxidative stress in hypertension

28 September 2017

1 reference

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Cholesterol metabolism deficiency

28 September 2017

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Regulation of mevalonate metabolism in cancer and immune cells.

28 September 2017

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Mitochondria as a pharmacological target: magnum overview

28 September 2017

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Specific inflammasomes in complex diseases

28 September 2017

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Mitochondrial dysfunction, oxidative stress and diabetic cardiovascular disorders

28 September 2017

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Mevalonate kinase deficiency: disclosing the role of mevalonate pathway modulation in inflammation

28 September 2017

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An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages

28 September 2017

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Protein farnesylation and disease

28 September 2017

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Mitochondrial ROS generation for regulation of autophagic pathways in cancer

28 September 2017

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Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome

28 September 2017

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Bisphosphonates: The first 40years

28 September 2017

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The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency.

28 September 2017

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Mitochondria removal by autophagy

28 September 2017

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Is oxidative stress a therapeutic target in cardiovascular disease?

28 September 2017

1 reference

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Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.

28 September 2017

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DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome

28 September 2017

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Dysregulation of the mevalonate pathway promotes transformation

28 September 2017

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Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

28 September 2017

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Toll-like receptors and NOD-like receptors in rheumatic diseases

28 September 2017

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

28 September 2017

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Adverse effects of bisphosphonates: current issues.

28 September 2017

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Genetic heterogeneity of autosomal dominant hypercholesterolemia.

28 September 2017

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Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells

28 September 2017

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Mitochondrial energy metabolism and redox state in dyslipidemias

28 September 2017

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Mitochondrial targeting of quinones: therapeutic implications.

28 September 2017

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Mitochondrial dysfunction in atherosclerosis.

28 September 2017

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Differences in nephrotoxicity of intravenous bisphosphonates for the treatment of malignancy-related bone disease

28 September 2017

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Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics

28 September 2017

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Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper

28 September 2017

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28 September 2017

Isoprenylated proteins

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Rho GTPases, statins, and nitric oxide

28 September 2017

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Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.

28 September 2017

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Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth.

28 September 2017

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Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.

28 September 2017

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Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB.

28 September 2017

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Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6.

28 September 2017

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New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

28 September 2017

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The gastrointestinal tolerability and safety of oral bisphosphonates

28 September 2017

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Pleiotropic effects of statins on the vascular tissue

28 September 2017

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Modulation of the inflammatory process by statins

28 September 2017

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Delivery of bioactive molecules to mitochondria in vivo.

28 September 2017

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Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival

28 September 2017

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Current drug treatments for lipid management.

28 September 2017

1 reference

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Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Hereditary periodic fever

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Inborn errors of cholesterol biosynthesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Selective targeting of an antioxidant to mitochondria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Clinical phenotype of desmosterolosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

An In Vitro and In Vivo Study of Cytokines in the Acute-Phase Response Associated with Bisphosphonates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

The biology of HMG-CoA reductase: the pros of contra-regulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

The CHILD syndrome. Congenital hemidysplasia with ichthyosiform erythroderma and limb defects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Hyperimmunoglobulinaemia D and periodic fever: a new syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

A new autosomal recessive lethal chondrodystrophy with congenital hydrops

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Mitochondrial electron transport-linked tocopheroxyl radical reduction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Hydroquinone Dehydrogenases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

The multifaceted nature of NLRP12.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Assay of ubiquinones and ubiquinols as antioxidants

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

31 May 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Disorders of cholesterol metabolism and their unanticipated convergent mechanisms of disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Emerging inflammasome effector mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Human astrocytes express a novel NLRP2 inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Targeting mitochondria as therapeutic strategy for metabolic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

The discovery and development of HMG-CoA reductase inhibitors. 1992.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Renal Failure with the Use of Zoledronic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, Phase III, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Role of Redox Signaling in the Autonomous Proliferative Response of Endothelial Cells to Hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Cholesterol metabolism and immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

Unilateral limb and skin deformities with congenital heart disease in two siblings: A lethal syndrome

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730292

Mitochondrial metabolism of reactive oxygen species

28 November 2018

1 reference

12 December 2020

Cutting edge: nitric oxide inhibits the NLRP3 inflammasome

1 reference

12 December 2020

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

1 reference

12 December 2020

Caspases: the proteases of the apoptotic pathway

1 reference

12 December 2020

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

1 reference

12 December 2020

Effect of first treatment with aminobisphosphonates pamidronate and ibandronate on circulating lymphocyte subpopulations

1 reference

12 December 2020

Smith-Lemli-Opitz (RSH) syndrome bibliography

1 reference

12 December 2020

The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles

1 reference

12 December 2020

Emerging lipid-lowering drugs: squalene synthase inhibitors

1 reference

12 December 2020

Clinical phenotype of desmosterolosis

1 reference

https://api.crossref.org/works/10.3390/IJMS17010047

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3390/IJMS17010047

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26729102 AND SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26729102 AND SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

26729102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26729102 AND SRC:MED&resulttype=core&format=json