The integrin-collagen connection--a glue for tissue repair? (Q26768149)

Up-regulation of a novel integrin alpha-chain (alpha mt) on human fetal myotubes

Europe PubMed Central

title

The integrin-collagen connection--a glue for tissue repair? (English)

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author name string

Cédric Zeltz

series ordinal

1

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Donald Gullberg

series ordinal

2

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language of work or name

English

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publication date

15 February 2016

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published in

Journal of Cell Science

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volume

129

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issue

4

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page(s)

653-64

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cites work

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Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice

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The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

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VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation.

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α11β1 integrin-mediated MMP-13-dependent collagen lattice contraction by fibroblasts: evidence for integrin-coordinated collagen proteolysis

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Glycated Collagen Induces α11 Integrin Expression Through TGF-β2 and Smad3

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Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.

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alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells

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Integrin α10β1: a collagen receptor critical in skeletal development

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Distribution of the collagen-binding integrin alpha10beta1 during mouse development

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Non-Smad signaling pathways

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An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice.

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Different beta 1-integrin collagen receptors on rat hepatocytes and cardiac fibroblasts.

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Osteonectin, a bone-specific protein linking mineral to collagen

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Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen

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Discoidin domain receptor functions in physiological and pathological conditions

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7 January 2021

Molecular composition and function of integrin-based collagen glues-introducing COLINBRIs

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Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes

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Integrin α1β1 participates in chondrocyte transduction of osmotic stress

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7 January 2021

Matrix crosslinking forces tumor progression by enhancing integrin signaling

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7 January 2021

LAIR and collagens in immune regulation

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7 January 2021

Integrin α1β1 differentially regulates cytokine-mediated responses in chondrocytes

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7 January 2021

Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (alpha2beta1gamma1), 8 (alpha4beta1gamma1), 10 (alpha5beta1gamma1)

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7 January 2021

The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner

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7 January 2021

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice.

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7 January 2021

Post-translational modifications of integrin ligands as pathogenic mechanisms in disease.

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7 January 2021

Shining new light on 3D cell motility and the metastatic process

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7 January 2021

The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens

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7 January 2021

Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources

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7 January 2021

Lumican inhibits cell migration through α2β1 integrin

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7 January 2021

Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing

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7 January 2021

Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury.

1 reference

7 January 2021

The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis

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7 January 2021

Collagen-binding I domain integrins--what do they do?

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7 January 2021

Structural basis of collagen recognition by integrin alpha2beta1

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7 January 2021

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

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7 January 2021

Integrins: bidirectional, allosteric signaling machines

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7 January 2021

Collagen remodelling in rat periodontal tissues: compensation for precursor reutilization confirms rapid turnover of collagen

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7 January 2021

The collagen receptor integrins have distinct ligand recognition and signaling functions

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7 January 2021

The discoidin domain receptor tyrosine kinases are activated by collagen

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7 January 2021

Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I.

1 reference

7 January 2021

Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors

1 reference

7 January 2021

Lack of Collagen VI Promotes Wound-Induced Hair Growth.

1 reference

7 January 2021

Reduced granulation tissue and wound strength in the absence of α11β1 integrin.

1 reference

7 January 2021

Anti-very late antigen-1 monoclonal antibody modulates the development of secondary lesion and T-cell response in experimental arthritis.

1 reference

7 January 2021

Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin

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7 January 2021

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

1 reference

7 January 2021

Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP

1 reference

7 January 2021

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.

1 reference

7 January 2021

Identification of a large set of rare complete human knockouts

1 reference

7 January 2021

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

1 reference

7 January 2021

Cancer as an overhealing wound: an old hypothesis revisited

1 reference

7 January 2021

Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis.

1 reference

7 January 2021

Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cells

1 reference

7 January 2021

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

1 reference

7 January 2021

Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization

1 reference

7 January 2021

What is the alpha2beta1 integrin doing in the epidermis?

1 reference

7 January 2021

Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression

1 reference

7 January 2021

Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.

1 reference

7 January 2021

Novel candidate tumor marker genes for lung adenocarcinoma

1 reference

7 January 2021

Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization

1 reference

7 January 2021

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

1 reference

7 January 2021

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

1 reference

7 January 2021

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

1 reference

7 January 2021

Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes

1 reference

7 January 2021

cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues

1 reference

7 January 2021

The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors

1 reference

7 January 2021

Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase

1 reference

7 January 2021

Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen

1 reference

7 January 2021

Integrin α2I Domain Recognizes Type I and Type IV Collagens by Different Mechanisms

1 reference

7 January 2021

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation

1 reference

7 January 2021

Integrin α1β1 Promotes Caveolin-1 Dephosphorylation by Activating T Cell Protein-tyrosine Phosphatase

1 reference

7 January 2021

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

1 reference

7 January 2021

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

1 reference

7 January 2021

Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.

1 reference

7 January 2021

Integrin α2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen

1 reference

7 January 2021

Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III.

1 reference

7 January 2021

Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions

1 reference

7 January 2021

Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance

1 reference

7 January 2021

Integrin-mediated cell adhesion to type I collagen fibrils

1 reference

7 January 2021

Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens

1 reference

7 January 2021

Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.

1 reference

7 January 2021

The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix

1 reference

7 January 2021

Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains

1 reference

7 January 2021

Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity

1 reference

7 January 2021

Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity

1 reference

7 January 2021

The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg -dependent adhesion of platelets to collagen

1 reference

7 January 2021

Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen

1 reference

7 January 2021

Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo

1 reference

7 January 2021

Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail

1 reference

7 January 2021

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.

1 reference

7 January 2021

Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential

1 reference

7 January 2021

Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt

1 reference

7 January 2021

α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy

1 reference

7 January 2021

The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism

1 reference

7 January 2021

Integrin genes and susceptibility to human melanoma.

1 reference

7 January 2021

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner

1 reference

7 January 2021

Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice

1 reference

7 January 2021

Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix

1 reference

7 January 2021

Effective treatment of mouse experimental colitis by alpha 2 integrin antibody: comparison with alpha 4 antibody and conventional therapy

1 reference

7 January 2021

Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1

1 reference

7 January 2021

Dynamic reciprocity in the wound microenvironment

1 reference

7 January 2021

Cell-matrix adhesion in vascular development

1 reference

7 January 2021

Integrin alpha1beta1 is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo

1 reference

7 January 2021

Physiology and pathology of collagen receptors.

1 reference

7 January 2021

The future of glycoprotein VI as an antithrombotic target.

1 reference

7 January 2021

The extracellular matrix: not just pretty fibrils

1 reference

7 January 2021

Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

1 reference

7 January 2021

The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

1 reference

7 January 2021

Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor

1 reference

7 January 2021

Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression

1 reference

7 January 2021

Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation

1 reference

7 January 2021

Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development

1 reference

7 January 2021

Transmembrane Collagen Receptors

1 reference

7 January 2021

Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration

1 reference

7 January 2021

The wound healing, chronic fibrosis, and cancer progression triad

1 reference

7 January 2021

Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone

1 reference

7 January 2021

Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer

1 reference

7 January 2021

GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2.

1 reference

7 January 2021

Phase I Study of E7820, an Oral Inhibitor of Integrin α-2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies

1 reference

7 January 2021

Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice

1 reference

7 January 2021

Mitigation of oxygen-induced retinopathy in α2β1 integrin-deficient mice.

1 reference

7 January 2021

Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis

1 reference

7 January 2021

The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells

1 reference

7 January 2021

The α2β1 integrin is a metastasis suppressor in mouse models and human cancer

1 reference

7 January 2021

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

1 reference

7 January 2021

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

1 reference

7 January 2021

An epigenetically distinct breast cancer cell subpopulation promotes collective invasion

1 reference

7 January 2021

Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and arthritis

1 reference

7 January 2021

The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivo

1 reference

7 January 2021

Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin

1 reference

7 January 2021

Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.

1 reference

7 January 2021

The genetics of normal platelet reactivity

1 reference

7 January 2021

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

1 reference

7 January 2021

Fibrin activates GPVI in human and mouse platelets

1 reference

7 January 2021

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

1 reference

7 January 2021

Collagen reorganization at the tumor-stromal interface facilitates local invasion

1 reference

7 January 2021

Collagen density promotes mammary tumor initiation and progression

1 reference

7 January 2021

Integrin α1 subunit is up-regulated in colorectal cancer

1 reference

7 January 2021

Specific expression of GPR56 by human cytotoxic lymphocytes.

1 reference

7 January 2021

The inhibitory collagen receptor LAIR-1 (CD305).

1 reference

7 January 2021

Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D.

1 reference

7 January 2021

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

1 reference

7 January 2021

Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes

1 reference

7 January 2021

Integrin signalling at a glance

1 reference

7 January 2021

Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin

1 reference

7 January 2021

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

1 reference

7 January 2021

Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation

1 reference

7 January 2021

Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro

1 reference

7 January 2021

Disease-associated mutations prevent GPR56-collagen III interaction

1 reference

7 January 2021

Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation

1 reference

7 January 2021

Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume

1 reference

7 January 2021

GPR56 functions together with α3β1 integrin in regulating cerebral cortical development

1 reference

7 January 2021

Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10.

1 reference

7 January 2021

Fibroblast α11β1 integrin regulates tensional homeostasis in fibroblast/A549 carcinoma heterospheroids

1 reference

7 January 2021

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis

1 reference

7 January 2021

Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase

1 reference

7 January 2021

Inhibition of integrin α2β1 ameliorates glomerular injury

1 reference

7 January 2021

GPR56 in cancer progression: current status and future perspective

1 reference

7 January 2021

Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α2β1 in Mice

1 reference

7 January 2021

Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome

1 reference

7 January 2021

Collagen XIII Induced in Vascular Endothelium Mediates α1β1 Integrin-Dependent Transmigration of Monocytes in Renal Fibrosis

1 reference

7 January 2021

Type I and Type III Collagen Content of Healing Wounds in Fetal and Adult Rats

1 reference

7 January 2021

Increased expression of alpha2beta1-integrin in the peritoneal dissemination of human gastric carcinoma

1 reference

7 January 2021

OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2 inflammatory monocytes

1 reference

7 January 2021

Collagen induces maturation of human monocyte-derived dendritic cells by signaling through osteoclast-associated receptor

1 reference

7 January 2021

Cooperation between IL-7 Receptor and Integrin α2β1 (CD49b) Drives Th17-Mediated Bone Loss.

1 reference

7 January 2021