Applications in image-based profiling of perturbations (Q26752791)

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The beautiful cell: high-content screening in drug discovery

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Small molecule screening by imaging

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https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Imaging in systems biology

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https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Cellular heterogeneity: do differences make a difference?

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A Hierarchical Map of Regulatory Genetic Interactions in Membrane Trafficking

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Saturated Reconstruction of a Volume of Neocortex

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Microscopy-Based High-Content Screening.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Phenotypic screens as a renewed approach for drug discovery

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Phenotype-Guided Natural Products Discovery Using Cytological Profiling.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Single-cell analysis of population context advances RNAi screening at multiple levels

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Systems survey of endocytosis by multiparametric image analysis

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A mesoscale connectome of the mouse brain

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

1 reference

7 January 2021

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The why and how of phenotypic small-molecule screens

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Image-based chemical screening

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Integrating high-content screening and ligand-target prediction to identify mechanism of action

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Identifying off-target effects and hidden phenotypes of drugs in human cells

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

High-throughput hyperdimensional vertebrate phenotyping.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Image-based multivariate profiling of drug responses from single cells

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

An approach for extensibly profiling the molecular states of cellular subpopulations

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

High-throughput behavioral analysis in C. elegans

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Biological imaging software tools

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Quantitative genetic-interaction mapping in mammalian cells

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Deducing the mechanism of action of compounds identified in phenotypic screens by integrating their multiparametric profiles with a reference genetic screen

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Measuring genetic interactions in human cells by RNAi and imaging

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

How were new medicines discovered?

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Tackling the widespread and critical impact of batch effects in high-throughput data

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

High-throughput functional genomics using CRISPR-Cas9.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Origins of regulated cell-to-cell variability

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

RNAi screening comes of age: improved techniques and complementary approaches

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Large-scale cytological profiling for functional analysis of bioactive compounds.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

High-dimensional and large-scale phenotyping of yeast mutants.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Characterizing heterogeneous cellular responses to perturbations

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

An algorithm-based topographical biomaterials library to instruct cell fate

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Plant-derived antifungal agent poacic acid targets β-1,3-glucan

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Linking phenotypes and modes of action through high-content screen fingerprints.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Multidimensional drug profiling by automated microscopy.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The genetic landscape of a cell

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Proteomics. Tissue-based map of the human proteome

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

An information-intensive approach to the molecular pharmacology of cancer.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Diversity of Ca2 -induced morphology revealed by morphological phenotyping of Ca2 -sensitive mutants of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Digital imaging in pathology: whole-slide imaging and beyond.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A cell profiling framework for modeling drug responses from HCS imaging

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Comparison of Multivariate Data Analysis Strategies for High-Content Screening

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Benchmarking of multivariate similarity measures for high-content screening fingerprints in phenotypic drug discovery

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension to Infinity and Beyond

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Increasing the Content of High-Content Screening: An Overview

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A Perspective on the Future of High-Throughput RNAi Screening: Will CRISPR Cut Out the Competition or Can RNAi Help Guide the Way?

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

High-Content Analysis of Breast Cancer Using Single-Cell Deep Transfer Learning

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Light microscopy applications in systems biology: opportunities and challenges

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A method for high-throughput gene expression signature analysis

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Machine learning in cell biology - teaching computers to recognize phenotypes

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

An unbiased cell morphology-based screen for new, biologically active small molecules

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Unsupervised clustering of subcellular protein expression patterns in high-throughput microscopy images reveals protein complexes and functional relationships between proteins

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

High-content, image-based screening for drug targets in yeast

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Vanillin inhibits translation and induces messenger ribonucleoprotein (mRNP) granule formation in saccharomyces cerevisiae: application and validation of high-content, image-based profiling

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Multiplex cytological profiling assay to measure diverse cellular states

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Personalized drug discovery: HCA approach optimized for rare diseases at Tel Aviv University

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Phenotypic fingerprinting of small molecule cell cycle kinase inhibitors for drug discovery

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Drosophila as a tool for personalized medicine: a primer

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

Computer vision for high content screening

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

In vitro clinical trials: the future of cell-based profiling

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021

A map of directional genetic interactions in a metazoan cell

1 reference

https://api.crossref.org/works/10.1016/J.COPBIO.2016.04.003

7 January 2021