Mechanisms of ferroptosis (Q26751418)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

8 February 2021

Mechanisms of ferroptosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

2 references

3 April 2019

8 February 2021

glutathione peroxidase

1 reference

28 September 2019

1 reference

12 October 2019

reactive oxygen species

1 reference

4 November 2019

1 reference

20 November 2019

1 reference

PubMed publication ID

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

author name string

Jennifer Yinuo Cao

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

language of work or name

English

0 references

publication date

5 April 2016

1 reference

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Cellular and Molecular Life Sciences

31 March 2020

1 June 2016

1 reference

8 February 2021

7 references

3 April 2019

28 September 2019

12 October 2019

4 November 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

8 February 2021

73

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

issue

11-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

page(s)

2195-2209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

31 March 2020

copyright license

6 references

3 April 2019

28 September 2019

12 October 2019

4 November 2019

20 November 2019

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

1 reference

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Mammalian long-chain acyl-CoA synthetases

7 April 2017

1 reference

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Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

7 April 2017

1 reference

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

7 April 2017

1 reference

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HSPB1 as a novel regulator of ferroptotic cancer cell death

7 April 2017

1 reference

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

7 April 2017

1 reference

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Mammalian lipoxygenases and their biological relevance

7 April 2017

1 reference

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Cell biology. Metabolic control of cell death

7 April 2017

1 reference

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Subcellular distribution of chelatable iron: a laser scanning microscopic study in isolated hepatocytes and liver endothelial cells

7 April 2017

1 reference

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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

7 April 2017

1 reference

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12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes

7 April 2017

1 reference

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

7 April 2017

1 reference

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The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

7 April 2017

1 reference

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Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

28 September 2017

1 reference

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Elucidating Compound Mechanism of Action by Network Perturbation Analysis.

28 September 2017

1 reference

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Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

28 September 2017

1 reference

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Glutaminolysis and Transferrin Regulate Ferroptosis

28 September 2017

1 reference

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Ferroptosis is Involved in Acetaminophen Induced Cell Death

28 September 2017

1 reference

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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

28 September 2017

1 reference

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Ferroptosis as a p53-mediated activity during tumour suppression

28 September 2017

1 reference

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xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseases

28 September 2017

1 reference

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Measuring glutathione redox potential of HIV-1-infected macrophages

28 September 2017

1 reference

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Synchronized renal tubular cell death involves ferroptosis.

28 September 2017

1 reference

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Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Unravelling mechanisms of p53-mediated tumour suppression

28 September 2017

1 reference

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Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

28 September 2017

1 reference

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Regulation of ferroptotic cancer cell death by GPX4

28 September 2017

1 reference

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The role of iron and reactive oxygen species in cell death

28 September 2017

1 reference

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Autosis is a Na ,K -ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

28 September 2017

1 reference

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Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

28 September 2017

1 reference

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Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

28 September 2017

1 reference

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The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress

28 September 2017

1 reference

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Programmed cell death in animal development and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Functional Model of Metabolite Gating by Human Voltage-Dependent Anion Channel 2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Apoptosis and glutathione: beyond an antioxidant.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Acyl-CoA:lysophospholipid acyltransferases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Amino acid metabolism in mammalian cell cultures

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Oxytosis: A novel form of programmed cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Use of isogenic human cancer cells for high-throughput screening and drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Glutathione deficiency is associated with impaired survival in HIV disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

The pantheon of the fallen: why are there so many forms of cell death?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Intralysosomal iron chelation protects against oxidative stress-induced cellular damage.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Thioredoxin reductase reduces lipid hydroperoxides and spares alpha-tocopherol

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Salmonella induces macrophage death by caspase-1-dependent necrosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4887533

Cystine deprivation induces oligodendroglial death: rescue by free radical scavengers and by a diffusible glial factor

28 November 2018

1 reference

12 December 2020

Nutrition needs of mammalian cells in tissue culture

1 reference

12 December 2020

The environment of the lipoxygenase iron binding site explored with novel hydroxypyridinone iron chelators

1 reference

12 December 2020

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

12 December 2020

Protective effect of levamisole and its sulfhydryl metabolite OMPI against cell death induced by glutathione depletion

1 reference

12 December 2020

Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity

1 reference

12 December 2020

Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine

1 reference

12 December 2020

Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium

1 reference

12 December 2020

The biosynthesis of cystine in human cell cultures

1 reference

12 December 2020

Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species Production In Vitro and In Vivo

1 reference

12 December 2020

10.1007/S00018-016-2194-1

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 March 2020

1028645128

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json

31 March 2020

PubMed publication ID

27048822

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27048822 AND SRC:MED&resulttype=core&format=json