SIRT1: A Novel Target for the Treatment of Muscular Dystrophies (Q26748736)

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1 April 2020

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13 November 2020

SIRT1: A Novel Target for the Treatment of Muscular Dystrophies (English)

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6 references

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1 April 2020

Yoshiyuki Horio

series ordinal

2

1 reference

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author name string

Atsushi Kuno

series ordinal

1

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Yoshiyuki Horio

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2

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language of work or name

English

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publication date

17 March 2016

6 references

13 March 2019

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28 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27073590 AND SRC:MED&resulttype=core&format=json

1 April 2020

13 November 2020

Oxidative Medicine and Cellular Longevity

8 references

13 March 2019

22 April 2019

25 April 2019

25 June 2019

28 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27073590 AND SRC:MED&resulttype=core&format=json

1 April 2020

13 November 2020

2016

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1 April 2020

page(s)

6714686

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Creative Commons Attribution 4.0 International

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on focus list of Wikimedia project

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cites work

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Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle

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Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy

7 April 2017

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Glutathione synthesis

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Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy

7 April 2017

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Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse

7 April 2017

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

7 April 2017

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Deacetylation of nuclear LC3 drives autophagy initiation under starvation

7 April 2017

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SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages

7 April 2017

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

7 April 2017

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Nucleocytoplasmic shuttling of the NAD -dependent histone deacetylase SIRT1

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

7 April 2017

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle

7 April 2017

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A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

7 April 2017

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Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

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A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy

7 April 2017

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28 September 2017

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Advances in Muscular Dystrophies

28 September 2017

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Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial

28 September 2017

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Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

28 September 2017

1 reference

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Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis

28 September 2017

1 reference

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Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function

28 September 2017

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Small molecule SIRT1 activators for the treatment of aging and age-related diseases

28 September 2017

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Treatment of dystrophin cardiomyopathies

28 September 2017

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Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy

28 September 2017

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Autophagy is Impaired in the Tibialis Anterior of Dystrophin Null Mice

28 September 2017

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Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress.

28 September 2017

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Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers

28 September 2017

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SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis

28 September 2017

1 reference

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Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein

28 September 2017

1 reference

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A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers

28 September 2017

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Contribution of oxidative stress to pathology in diaphragm and limb muscles with Duchenne muscular dystrophy

28 September 2017

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Differential cell-protective function of two resveratrol (trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress.

28 September 2017

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Targeting the TGFβ signalling pathway in disease

28 September 2017

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Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

28 September 2017

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

28 September 2017

1 reference

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SIRT1 signaling as potential modulator of skeletal muscle diseases.

28 September 2017

1 reference

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Oxidative damage in muscular dystrophy correlates with the severity of the pathology: role of glutathione metabolism

28 September 2017

1 reference

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δ-Sarcoglycan-deficient muscular dystrophy: from discovery to therapeutic approaches

28 September 2017

1 reference

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Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle

28 September 2017

1 reference

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Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy.

28 September 2017

1 reference

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Cellular and molecular effects of sirtuins in health and disease.

28 September 2017

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AMP‐activated protein kinase inhibits TGF‐β‐induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300

28 September 2017

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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

28 September 2017

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Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse

28 September 2017

1 reference

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MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382.

28 September 2017

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Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3

28 September 2017

1 reference

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SirT1 in muscle physiology and disease: lessons from mouse models.

28 September 2017

1 reference

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

28 September 2017

1 reference

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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

28 September 2017

1 reference

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NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.

28 September 2017

1 reference

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GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation

28 September 2017

1 reference

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STAT3 inhibition of gluconeogenesis is downregulated by SirT1

28 September 2017

1 reference

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Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

28 September 2017

1 reference

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

28 September 2017

1 reference

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Protein-DNA array-based identification of transcription factor activities differentially regulated in skeletal muscle of normal and dystrophin-deficient mdx mice.

28 September 2017

1 reference

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Dynamic FoxO transcription factors

28 September 2017

1 reference

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Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Regulation of Nox and Duox enzymatic activity and expression

28 September 2017

1 reference

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The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans

28 September 2017

1 reference

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Autophagy as a new therapeutic target in Duchenne muscular dystrophy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Inhibiting TGF-β Activity Improves Respiratory Function in mdx Mice

31 May 2018

1 reference

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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Reciprocal amplification of ROS and Ca(2 ) signals in stressed mdx dystrophic skeletal muscle fibers.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Impact of prednisone on TGF-beta1 and collagen in diaphragm muscle from mdx mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4814699

Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study

31 May 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of Duchenne muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Patients with dystrophinopathy show evidence of increased oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-β/Smad3 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Endomysial fibrosis in Duchenne muscular dystrophy: a marker of poor outcome associated with macrophage alternative activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Autophagy is required to maintain muscle mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1155/2016/6714686

Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state

21 January 2018

1 reference

12 December 2020

The muscular dystrophies

1 reference

12 December 2020

1 reference

12 December 2020

Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy

1 reference

12 December 2020

Resveratrol improves muscle function but not oxidative capacity in young mdx mice

1 reference

12 December 2020

Smad3 is acetylated by p300/CBP to regulate its transactivation activity

1 reference

12 December 2020

Amplification of proinflammatory phenotype, damage, and weakness by oxidative stress in the diaphragm muscle of mdx mice

1 reference

12 December 2020

Identifiers

DOI

10.1155/2016/6714686

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27073590 AND SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27073590 AND SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

27073590

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27073590 AND SRC:MED&resulttype=core&format=json