Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution (Q26269828)

17

0 references

Jin Liu

Jin Liu

6

0 references

Carlo Camilloni

Carlo Camilloni

4

0 references

Diana R. Tomchick

Diana R Tomchick

16

0 references

Daniel Häussinger

Daniel Häussinger

14

0 references

Josep Rizo

20

Josep Rizo

0 references

Taulant Bacaj

2

Taulant Bacaj

0 references

author name string

Kyle D Brewer

1

0 references

Andrea Cavalli

3

0 references

James D Swarbrick

5

0 references

Amy Zhou

7

0 references

Peng Zhou

8

0 references

Nicholas Barlow

9

0 references

Junjie Xu

10

0 references

Alpay B Seven

11

0 references

Eric A Prinslow

12

0 references

Rashmi Voleti

13

0 references

Alexandre M J J Bonvin

15

0 references

Bim Graham

Nature Structural & Molecular Biology

18

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language of work or name

English

0 references

publication date

July 2015

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published in

0 references

volume

22

0 references

issue

7

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page(s)

555-64

0 references

cites work

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Differential but convergent functions of Ca2 binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

7 April 2017

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Complexin controls the force transfer from SNARE complexes to membranes in fusion

7 April 2017

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7 April 2017

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Three-dimensional structure of the complexin/SNARE complex

7 April 2017

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Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

7 April 2017

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Solution structures of the Ca2 -free and Ca2 -bound C2A domain of synaptotagmin I: does Ca2 induce a conformational change?

7 April 2017

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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

7 April 2017

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Structure of the first C2 domain of synaptotagmin I: A novel Ca2 /phospholipid-binding fold

7 April 2017

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7 April 2017

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Interactions between macromolecules and ions: The Hofmeister series

7 April 2017

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A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

7 April 2017

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Ca2 -dependent synaptotagmin binding to SNAP-25 is essential for Ca2 -triggered exocytosis

7 April 2017

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Synaptotagmin I functions as a calcium regulator of release probability

7 April 2017

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The C terminus of SNAP25 is essential for Ca(2 )-dependent binding of synaptotagmin to SNARE complexes

7 April 2017

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Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones

7 April 2017

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Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Re-examining how complexin inhibits neurotransmitter release

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Prevalent mechanism of membrane bridging by synaptotagmin-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release

28 September 2017

1 reference

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Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release

28 September 2017

1 reference

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The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?

28 September 2017

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Complexin arrests a pool of docked vesicles for fast Ca2 -dependent release

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings

28 September 2017

1 reference

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Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Synaptotagmin 1 and SNAREs Form a Complex That Is Structurally Heterogeneous

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Protein NMR using paramagnetic ions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Observing biological dynamics at atomic resolution using NMR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Methyl groups as probes of supra-molecular structure, dynamics and function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Single-molecule studies of the neuronal SNARE fusion machinery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Numbat: an interactive software tool for fitting Deltachi-tensors to molecular coordinates using pseudocontact shifts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Synaptotagmin C2A loop 2 mediates Ca2 -dependent SNARE interactions essential for Ca2 -triggered vesicle exocytosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

A clamping mechanism involved in SNARE-dependent exocytosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Complexins regulate a late step in Ca2 -dependent neurotransmitter release

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

The Ca2 affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

A quaternary SNARE-synaptotagmin-Ca2 -phospholipid complex in neurotransmitter release

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

Conserved prefusion protein assembly in regulated exocytosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496268

The synaptic SNARE complex is a parallel four-stranded helical bundle

31 May 2018

1 reference

Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions

21 January 2018

1 reference

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2 -dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

21 January 2018

1 reference

Hemifusion arrest by complexin is relieved by Ca2 -synaptotagmin I.

21 January 2018

1 reference

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

21 January 2018

1 reference

Distinct domains of complexin I differentially regulate neurotransmitter release

21 January 2018

1 reference

Ca2 regulates the interaction between synaptotagmin and syntaxin 1.

21 January 2018

1 reference

Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex

21 January 2018

1 reference

Avoiding nonspecific interactions in studies of the plasma proteome: practical solutions to prevention of nonspecific interactions for label-free detection of low-abundance plasma proteins.

21 January 2018

1 reference

How reliable are pseudocontact shifts induced in proteins and ligands by mobile paramagnetic metal tags? A modelling study

21 January 2018

1 reference

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

21 January 2018

1 reference

Synaptotagmin-1, -2, and -9: Ca(2 ) sensors for fast release that specify distinct presynaptic properties in subsets of neurons

21 January 2018

1 reference

Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation

21 January 2018

1 reference

DOTA-Amide Lanthanide Tag for Reliable Generation of Pseudocontact Shifts in Protein NMR Spectra

21 January 2018

1 reference

Close membrane-membrane proximity induced by Ca(2 )-dependent multivalent binding of synaptotagmin-1 to phospholipids

21 January 2018

1 reference

Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy

31 March 2020

1 reference

Are neuronal SNARE proteins Ca2 sensors?

31 March 2020

1 reference

Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.3035

1 reference

Dimensions Publication ID

1052784931

0 references

1 reference

1 reference

PubMed publication ID

26030874

1 reference