Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion (Q24683255)

1

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P Z Anastasiadis

2

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J M Daniel

3

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R C Ireton

4

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M J Wheelock

5

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K R Johnson

6

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D K Hummingbird

7

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A B Reynolds

Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression

8

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language of work or name

English

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publication date

10 January 2000

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published in

Journal of Cell Biology

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volume

148

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issue

1

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page(s)

189-202

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cites work

1 reference

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p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells

7 April 2017

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The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor

7 April 2017

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delta-catenin, an adhesive junction-associated protein which promotes cell scattering

7 April 2017

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The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn

7 April 2017

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Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization

7 April 2017

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

7 April 2017

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

7 April 2017

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E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers

7 April 2017

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Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes

7 April 2017

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E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

7 April 2017

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Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin

7 April 2017

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The Tyrosine Kinase Substrate p120cas Binds Directly to E-Cadherin but Not to the Adenomatous Polyposis Coli Protein or α-Catenin

7 April 2017

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Cell binding function of E-cadherin is regulated by the cytoplasmic domain

7 April 2017

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The uvomorulin-anchorage protein alpha catenin is a vinculin homologue

7 April 2017

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p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity

7 April 2017

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Cadherin-11 is expressed in invasive breast cancer cell lines

7 April 2017

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Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells

7 April 2017

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Functional interaction of beta-catenin with the transcription factor LEF-1

7 April 2017

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The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts

7 April 2017

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A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines

7 April 2017

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A repeating amino acid motif shared by proteins with diverse cellular roles

7 April 2017

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Assembly of the cadherin-catenin complex in vitro with recombinant proteins

7 April 2017

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Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex

7 April 2017

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The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression

7 April 2017

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XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

7 April 2017

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Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin

7 April 2017

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A causal role for E-cadherin in the transition from adenoma to carcinoma

7 April 2017

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Morphogenetic roles of classic cadherins

7 April 2017

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

7 April 2017

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N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression

7 April 2017

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The oncogenic activation of beta-catenin

28 September 2017

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Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells

28 September 2017

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Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein

28 September 2017

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Production and characterization of monoclonal antibodies to the catenin p120ctn

28 September 2017

1 reference

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The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin

28 September 2017

1 reference

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Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Uncoupling of XB/U-cadherin-catenin complex formation from its function in cell-cell adhesion

28 September 2017

1 reference

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E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Cross-talk between adherens junctions and desmosomes depends on plakoglobin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

28 September 2017

1 reference

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Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Molecular and functional analysis of cadherin-based adherens junctions

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Dephosphorylation of the cadherin-associated p100/p120 proteins in response to activation of protein kinase C in epithelial cells.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps.

30 May 2018

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Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2156209

Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083/JCB.148.1.189

Cell adhesion and signal transduction: the Armadillo connection

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083/JCB.148.1.189

The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review

21 January 2018

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12 December 2020

A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated

1 reference

12 December 2020

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1 reference

12 December 2020

Prognostic value of cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120cas) in bladder tumors

1 reference

12 December 2020

Abnormal expression of p120 correlates with poor survival in patients with bladder cancer

1 reference

12 December 2020

p120-catenin expression in human colorectal cancer

1 reference

12 December 2020

Cytomechanics of cadherin-mediated cell-cell adhesion

1 reference

12 December 2020

Loss of p120ctn in human colorectal cancer predicts metastasis and poor survival

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.148.1.189

1 reference

1 reference

1 reference

PubMed publication ID

10629228

1 reference