Alternatively spliced isoforms of the human constitutive androstane receptor (Q24679627)

1

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Richard Ramsden

2

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Matthew A Stoner

3

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Christophe Verlinde

4

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Christopher Hassett

5

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Curtis J Omiecinski

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

6

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language of work or name

English

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publication date

15 June 2003

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published in

Nucleic Acids Research

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volume

31

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issue

12

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page(s)

3194-207

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cites work

1 reference

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Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms

7 April 2017

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

7 April 2017

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

7 April 2017

1 reference

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

7 April 2017

1 reference

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

7 April 2017

1 reference

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

7 April 2017

1 reference

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

7 April 2017

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

7 April 2017

1 reference

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

7 April 2017

1 reference

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Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

7 April 2017

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

7 April 2017

1 reference

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Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

7 April 2017

1 reference

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Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

7 April 2017

1 reference

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Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

7 April 2017

1 reference

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

7 April 2017

1 reference

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Protein structure prediction and structural genomics

7 April 2017

1 reference

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

7 April 2017

1 reference

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Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

7 April 2017

1 reference

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The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

7 April 2017

1 reference

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A unified nomenclature system for the nuclear receptor superfamily

7 April 2017

1 reference

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

7 April 2017

1 reference

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Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

7 April 2017

1 reference

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An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

7 April 2017

1 reference

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Alternative pre-mRNA splicing and proteome expansion in metazoans

7 April 2017

1 reference

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A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity

7 April 2017

1 reference

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Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

28 September 2017

1 reference

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Killing the messenger: new insights into nonsense-mediated mRNA decay

28 September 2017

1 reference

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

28 September 2017

1 reference

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Novel N-terminal variant of human VDR.

28 September 2017

1 reference

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Orphan nuclear receptors: the exotics of xenobiotics.

28 September 2017

1 reference

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Binding of ligands and activation of transcription by nuclear receptors.

28 September 2017

1 reference

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Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

28 September 2017

1 reference

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Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor.

28 September 2017

1 reference

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

28 September 2017

1 reference

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Nuclear hormone receptor coregulators in action: diversity for shared tasks

28 September 2017

1 reference

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Modulating nuclear receptor function: may the phos be with you

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

A four-amino-acid insertion in the ligand-binding domain inactivates hRXRbeta and renders dominant negative activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Ah receptor signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

The human cDNA sequence homologous to the mouse MHC class I promoter-binding protein gene contains four additional codons in lymphocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

Heterodimerization preferences of thyroid hormone receptor alpha isoforms.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162252

28 November 2018

Identifiers

DOI

10.1093/NAR/GKG419

1 reference

release_gumit5alabhlzpjj46ritnhh3i

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gumit5alabhlzpjj46ritnhh3i

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

1 reference

PubMed publication ID

12799447

1 reference