Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors (Q24678647)

2

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Ganka V Nikolova

3

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Darren Carpizo

4

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M Luisa Iruela-Arispe

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

5

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language of work or name

English

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publication date

23 May 2005

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published in

Journal of Cell Biology

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volume

169

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issue

4

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page(s)

681-91

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cites work

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Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin

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Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

7 April 2017

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7 April 2017

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Angiogenesis in cancer and other diseases

7 April 2017

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ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

7 April 2017

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The splice variants of vascular endothelial growth factor (VEGF) and their receptors

7 April 2017

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

7 April 2017

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Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

7 April 2017

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

7 April 2017

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

7 April 2017

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

7 April 2017

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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

7 April 2017

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Vascular development and patterning: making the right choices

7 April 2017

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Imaging of angiogenesis: from microscope to clinic

28 September 2017

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TACE is required for the activation of the EGFR by TGF-alpha in tumors

28 September 2017

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Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

28 September 2017

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Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy

28 September 2017

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Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

28 September 2017

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VEGF and the quest for tumour angiogenesis factors

28 September 2017

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Strategies for MMP inhibition in cancer: innovations for the post-trial era.

28 September 2017

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Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

28 September 2017

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Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

28 September 2017

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Cell-cell interactions in vascular development

28 September 2017

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Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants.

28 September 2017

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PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor

28 September 2017

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VEGF: an update on biological and therapeutic aspects

28 September 2017

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Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

28 September 2017

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Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization

28 September 2017

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Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor

28 September 2017

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Disulfide Structure of the Heparin Binding Domain in Vascular Endothelial Growth Factor: Characterization of Posttranslational Modifications in VEGF

28 September 2017

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Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3.

28 September 2017

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The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

28 September 2017

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The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.

28 September 2017

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The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

28 September 2017

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Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect.

28 September 2017

1 reference

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Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms

30 May 2018

1 reference

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Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

30 May 2018

1 reference

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Extracellular matrix‐bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171712

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171712

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171712

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171712

Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2171712

Formation of endothelial cell networks

28 November 2018

1 reference

12 December 2020

Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance

1 reference

12 December 2020

Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation

1 reference

12 December 2020

VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix

1 reference

12 December 2020

Progesterone regulates proliferation of endothelial cells

1 reference

12 December 2020

VEGF is required for growth and survival in neonatal mice

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200409115

1 reference

1 reference

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PubMed publication ID

15911882

1 reference