Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1 (Q24672149)

Presenilin 1

1 reference

Low density lipoprotein receptor-related protein 1

1 reference

Alpha-2-macroglobulin

1 reference

Amyloid beta (A4) precursor protein

1 reference

Amyloid beta (A4) precursor-like protein 2

1 reference

1 reference

Qiang Liu

1

0 references

Celina V Zerbinatti

2

0 references

Juan Zhang

3

0 references

Hyang-Sook Hoe

4

0 references

Baiping Wang

5

0 references

Sarah L Cole

6

0 references

Joachim Herz

7

0 references

Louis Muglia

8

0 references

Guojun Bu

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

9

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language of work or name

English

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publication date

4 October 2007

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published in

Neuron

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volume

56

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issue

1

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page(s)

66-78

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cites work

1 reference

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7 April 2017

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Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding

7 April 2017

1 reference

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Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

7 April 2017

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 April 2017

1 reference

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Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

7 April 2017

1 reference

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

7 April 2017

1 reference

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39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

7 April 2017

1 reference

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Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

7 April 2017

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

7 April 2017

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

7 April 2017

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Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

7 April 2017

1 reference

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Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

7 April 2017

1 reference

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

7 April 2017

1 reference

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Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

7 April 2017

1 reference

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Alzheimer's disease: the cholesterol connection

7 April 2017

1 reference

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Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

7 April 2017

1 reference

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

7 April 2017

1 reference

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Subregion- and cell type-restricted gene knockout in mouse brain

7 April 2017

1 reference

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

7 April 2017

1 reference

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Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

7 April 2017

1 reference

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Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

7 April 2017

1 reference

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

7 April 2017

1 reference

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Isoform-specific binding of apolipoprotein E to beta-amyloid

7 April 2017

1 reference

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

7 April 2017

1 reference

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Overview: the long and winding road to understanding Alzheimer's disease

28 September 2017

1 reference

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The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

28 September 2017

1 reference

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Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

28 September 2017

1 reference

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Reelin, lipoprotein receptors and synaptic plasticity

28 September 2017

1 reference

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Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies.

28 September 2017

1 reference

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Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?

28 September 2017

1 reference

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Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

28 September 2017

1 reference

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Cholesterol in Alzheimer's disease

28 September 2017

1 reference

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LRP and Alzheimer's disease

28 September 2017

1 reference

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Neurovascular mechanisms of Alzheimer's neurodegeneration

28 September 2017

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Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.

28 September 2017

1 reference

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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

28 September 2017

1 reference

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Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

28 September 2017

1 reference

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Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

28 September 2017

1 reference

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Cholesterol homeostasis and function in neurons of the central nervous system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045076

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

28 September 2017

1 reference

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Lipoprotein receptors in the nervous system

28 September 2017

1 reference

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

28 September 2017

1 reference

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Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

28 September 2017

1 reference

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

28 September 2017

1 reference

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

28 September 2017

1 reference

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Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

28 September 2017

1 reference

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

30 May 2018

1 reference

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Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells.

30 May 2018

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30 May 2018

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Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

30 May 2018

1 reference

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Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554

30 May 2018

1 reference

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Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

28 November 2018

1 reference

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Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice

28 November 2018

1 reference

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Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

28 November 2018

1 reference

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The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

28 November 2018

1 reference

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045076

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045076

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045076

Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice

28 November 2018

1 reference

12 December 2020

The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein

1 reference

12 December 2020

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

12 December 2020

Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554

1 reference

12 December 2020

10.1016/J.NEURON.2007.08.008

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

17920016

1 reference