The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase (Q24670362)

Gene Ontology release 2020-05-02

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0070763

A disintegrin and metallopeptidase domain 10

1 reference

GOA release 2020-03-11

Presenilin 1

1 reference

Delta like canonical Notch ligand 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Neetu Gupta-Rossi

5

0 references

Emmanuelle M. Six

object named as

Emmanuelle Six

1

0 references

Alain Israel

6

object named as

Alain Israel

0 references

author name string

Delphine Ndiaye

2

0 references

Yacine Laabi

3

0 references

Christel Brou

4

0 references

Frederique Logeat

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

0 references

publication date

24 June 2003

0 references

published in

0 references

volume

100

0 references

issue

13

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page(s)

7638-43

0 references

cites work

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

1 reference

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

7 April 2017

1 reference

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

7 April 2017

1 reference

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MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

The Notch1 receptor is cleaved constitutively by a furin-like convertase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Notch signaling: cell fate control and signal integration in development

7 April 2017

1 reference

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

7 April 2017

1 reference

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

7 April 2017

1 reference

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Regulated cleavage of a contact-mediated axon repellent

7 April 2017

1 reference

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

7 April 2017

1 reference

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

7 April 2017

1 reference

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Presenilin is required for activity and nuclear access of Notch in Drosophila

7 April 2017

1 reference

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 April 2017

1 reference

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A growing family of Notch ligands

7 April 2017

1 reference

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 April 2017

1 reference

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Signalling downstream of activated mammalian Notch

7 April 2017

1 reference

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Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

7 April 2017

1 reference

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Plat-E: an efficient and stable system for transient packaging of retroviruses

7 April 2017

1 reference

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Notch-induced proteolysis and nuclear localization of the Delta ligand

7 April 2017

1 reference

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The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

28 September 2017

1 reference

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The ADAMs family of metalloproteases: multidomain proteins with multiple functions

28 September 2017

1 reference

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The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

28 September 2017

1 reference

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Down-regulation of Delta by proteolytic processing

28 September 2017

1 reference

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

kuzbanian-mediated cleavage of Drosophila Notch

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Processing of the notch ligand delta by the metalloprotease Kuzbanian

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=164639

The NOTCH receptor and its ligands

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12794186

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12794186

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Delta regulates keratinocyte spreading and motility independently of differentiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12794186

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1230693100

1 reference

ADS bibcode

2003PNAS..100.7638S

0 references

1 reference

1 reference

PubMed publication ID

12794186

1 reference