Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G (Q24651040)

2

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S Nakamura

3

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H Kitayama

4

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M Noda

5

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Y Takai

6

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K Kaibuchi

7

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H Matsui

8

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O Hatase

9

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H Takahashi

Molecular and Cellular Biology

10

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language of work or name

English

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publication date

December 1995

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published in

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volume

15

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issue

12

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page(s)

6746-53

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cites work

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CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

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Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

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Molecular cloning of smg p21B and identification of smg p21 purified from bovine brain and human platelets as smg p21B

7 April 2017

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Two species of human CRK cDNA encode proteins with distinct biological activities

7 April 2017

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

7 April 2017

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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

7 April 2017

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

7 April 2017

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SH2 domains recognize specific phosphopeptide sequences

7 April 2017

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

7 April 2017

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SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

7 April 2017

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A putative modular domain present in diverse signaling proteins

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

7 April 2017

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

7 April 2017

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Identification of a ten-amino acid proline-rich SH3 binding site

7 April 2017

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Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

7 April 2017

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A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization

7 April 2017

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Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region

7 April 2017

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A novel viral oncogene with structural similarity to phospholipase C

7 April 2017

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RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

7 April 2017

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Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

7 April 2017

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

7 April 2017

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

7 April 2017

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

7 April 2017

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

7 April 2017

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SH2 and SH3 domains: from structure to function

7 April 2017

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Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells

7 April 2017

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How receptor tyrosine kinases activate Ras.

28 September 2017

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SH2/SH3 signaling proteins

28 September 2017

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Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

28 September 2017

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pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

28 September 2017

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Crk interacts with tyrosine-phosphorylated p116 upon T cell activation

28 September 2017

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Closing in on SH2 specificity

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Human Colon Carcinoma Ki-ras2 Oncogene and Its Corresponding Proto-Oncogene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

The Son of sevenless Gene Product: a Putative Activator of Ras

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 Cells Induces DNA Synthesis and Morphological Changes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Baculovirus expression vectors: the requirements for high level expression of proteins, including glycoproteins

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

In vivo functional analysis of the Ras exchange factor son of sevenless

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230928

Translocation of Ki-ras p21 between membrane and cytoplasm by smg GDS

28 November 2018

1 reference

12 December 2020

A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins

1 reference

12 December 2020

Different functions of Smg GDP dissociation stimulator and mammalian counterpart of yeast Cdc25

1 reference

12 December 2020

Activation of the c-fos serum-response element by the activated c-Ha-ras protein in a manner independent of protein kinase C and cAMP-dependent protein kinase

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.15.12.6746

1 reference

1 reference

1 reference

PubMed publication ID

8524240

1 reference