Expanding the genetic code for biological studies (Q24645611)

An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides

Europe PubMed Central

title

Expanding the genetic code for biological studies (English)

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Qian Wang

1

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Angela R Parrish

series ordinal

2

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Lei Wang

series ordinal

3

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language of work or name

English

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publication date

27 March 2009

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published in

Chemistry and Biology

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volume

16

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issue

3

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page(s)

323-36

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cites work

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Twenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteria

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Rewiring the keyboard: evolvability of the genetic code

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A genetically encoded diazirine photocrosslinker in Escherichia coli

7 April 2017

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A genetically encoded bidentate, metal-binding amino acid

7 April 2017

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Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate

7 April 2017

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A genetically encoded photocaged amino acid

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An expanded eukaryotic genetic code

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Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression

7 April 2017

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Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli

7 April 2017

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Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli

7 April 2017

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Expanding the genetic code of Escherichia coli

7 April 2017

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Construction of Escherichia coli amber suppressor tRNA genes. III. Determination of tRNA specificity

7 April 2017

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7 April 2017

Aminoacyl-tRNA synthesis

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Synthesis of proteins by native chemical ligation

7 April 2017

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Immunochemical termination of self-tolerance

7 April 2017

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In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy

27 September 2017

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Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

27 September 2017

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Unnatural amino acid replacement in a yeast G protein-coupled receptor in its native environment

27 September 2017

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Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

27 September 2017

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Control of protein phosphorylation with a genetically encoded photocaged amino acid

27 September 2017

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Tunable photoactivation of a post-translationally modified signaling protein and its unmodified counterpart in live cells

27 September 2017

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Site-specific incorporation of a (19)F-amino acid into proteins as an NMR probe for characterizing protein structure and reactivity.

27 September 2017

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Natural expansion of the genetic code

27 September 2017

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A genetically encoded infrared probe.

27 September 2017

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Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't

27 September 2017

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Early nonsense: mRNA decay solves a translational problem

27 September 2017

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The genetic incorporation of a distance probe into proteins in Escherichia coli.

27 September 2017

1 reference

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Selective Staudinger modification of proteins containing p-azidophenylalanine

27 September 2017

1 reference

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Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

27 September 2017

1 reference

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A new strategy for the synthesis of glycoproteins.

27 September 2017

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Non-canonical amino acids in protein engineering

27 September 2017

1 reference

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Unnatural amino acid mutagenesis in mapping ion channel function.

27 September 2017

1 reference

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A new strategy for the site-specific modification of proteins in vivo.

27 September 2017

1 reference

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Semisynthesis of proteins by expressed protein ligation

27 September 2017

1 reference

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A method for the generation of glycoprotein mimetics

27 September 2017

1 reference

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Addition of the keto functional group to the genetic code of Escherichia coli.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696486

Incorporation of non-natural amino acids into proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696486

Expanding the genetic code

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696486

Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA.

27 September 2017

1 reference

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A general approach for the generation of orthogonal tRNAs.

27 September 2017

1 reference

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An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene

27 September 2017

1 reference

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Recognition and silencing of repeated DNA.

27 September 2017

1 reference

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Survey and summary: transcription by RNA polymerases I and III.

27 September 2017

1 reference

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Amber suppression in mammalian cells dependent upon expression of an Escherichia coli aminoacyl-tRNA synthetase gene

27 September 2017

1 reference

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RNA polymerase III. Genes, factors and transcriptional specificity.

27 September 2017

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Chemical synthesis of peptides and proteins

27 September 2017

1 reference

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The chemical modification of enzymatic specificity

27 September 2017

1 reference

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A general method for site-specific incorporation of unnatural amino acids into proteins.

27 September 2017

1 reference

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Expression and function of a human initiator tRNA gene in the yeast Saccharomyces cerevisiae

27 September 2017

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Selenocysteine: the 21st amino acid

27 September 2017

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A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase

27 September 2017

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Posttranslational Covalent Modification of Proteins

27 September 2017

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27 September 2017

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Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli

30 May 2018

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Biosynthesis of a site-specific DNA cleaving protein

30 May 2018

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Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins

28 November 2018

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Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases

28 November 2018

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28 November 2018

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A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli.

28 November 2018

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An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae.

28 November 2018

1 reference

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Genetic incorporation of unnatural amino acids into proteins in mammalian cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2696486

A genetically encoded fluorescent amino acid.

28 November 2018

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A genetically encoded photocaged tyrosine

28 November 2018

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The incorporation of a photoisomerizable amino acid into proteins in E. coli

28 November 2018

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Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid

28 November 2018

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Site-specific PEGylation of proteins containing unnatural amino acids

28 November 2018

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The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination

28 November 2018

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Substrate recognition by the AAA chaperone ClpB.

28 November 2018

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Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae

28 November 2018

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Computational modeling and experimental analysis of nonsense-mediated decay in yeast

28 November 2018

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Generation of a bacterium with a 21 amino acid genetic code

28 November 2018

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Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli

28 November 2018

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Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

28 November 2018

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Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements

28 November 2018

1 reference

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A biosynthetic route to dehydroalanine-containing proteins

28 November 2018

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12 December 2020

Evolutionary relationship between Halobacterium cutirubrum and eukaryotes determined by use of aminoacyl-tRNA synthetases as phylogenetic probes

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12 December 2020

[Total replacement of methionine by selenomethionine in the proteins of Escherichia coli]

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Expanding the Genetic Code

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12 December 2020

Ion selectivity in a semisynthetic K channel locked in the conductive conformation

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12 December 2020

A New Functional Suppressor tRNA/Aminoacyl−tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins

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Crossref

https://api.crossref.org/works/10.1016/J.CHEMBIOL.2009.03.001

7 January 2021