LYN proto-oncogene, Src family tyrosine kinase (Q2463389)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

Src family kinases (SFKs) [cytosol]

0 references

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase Lyn, SH3 domain, protein family

1 reference

SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Tyrosine-protein kinase Lyn, SH2 domain, protein family

1 reference

transmembrane transporter binding

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

SH3 domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

kinase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948

1 reference

31 January 2017

gamma-tubulin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

non-membrane spanning protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

platelet-derived growth factor receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

integrin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

protein binding

26 references

8 April 2019

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef viruses but not for down-regulation of CD4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Leupaxin negatively regulates B cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

glycosphingolipid binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

15 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Vav2 is required for cell spreading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Protein kinase C theta is expressed in mast cells and is functionally involved in Fcepsilon receptor I signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

phosphoprotein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

ubiquitin protein ligase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

enzyme binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

ephrin receptor binding

1 reference

8 April 2019

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

phosphorylation-dependent protein binding

1 reference

8 April 2019

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

cell component

cytoplasm

ISS

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

mitochondrial intermembrane space

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

mitochondrial membranes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

4 references

8 April 2019

8 April 2019

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

postsynaptic density

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

mast cell granule

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

integrin alpha2-beta1 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

mitochondrial crista

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

membrane raft

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

HDA

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

postsynaptic specialization, intracellular component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

regulation of protein phosphorylation

biological process

1 reference

8 April 2019

Src-family kinases in B-cell development and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

cellular response to extracellular stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

cellular response to retinoic acid

1 reference

8 April 2019

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of B cell receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

tolerance induction to self antigen

ISS

regulation of cell adhesion mediated by integrin

3 references

1 reference

8 April 2019

Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

cellular response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

hemopoiesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

cellular response to DNA damage stimulus

positive regulation of Fc receptor mediated stimulatory signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

Fc-epsilon receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of dendritic cell apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of glial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

response to carbohydrate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

regulation of platelet aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

B cell receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

negative regulation of myeloid leukocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

dendritic cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

Fc-gamma receptor signaling pathway involved in phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

31 January 2017

Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948

regulation of B cell receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

stimulatory C-type lectin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

response to sterol depletion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of stress-activated protein kinase signaling cascade

1 reference

8 April 2019

Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

response to insulin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of mast cell proliferation

1 reference

8 April 2019

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

oligodendrocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

regulation of mast cell degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

response to toxic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

Fc receptor mediated stimulatory signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

growth hormone receptor signaling pathway via JAK-STAT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

immune response-regulating cell surface receptor signaling pathway

Src-family kinases in B-cell development and signaling

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

response to axon injury

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

negative regulation of mast cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

regulation of inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

regulation of monocyte chemotaxis

1 reference

8 April 2019

Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

leukocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

histamine secretion by mast cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

intracellular signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

ephrin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

T cell costimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

response to peptide hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

platelet degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

blood coagulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

positive regulation of phosphatidylinositol 3-kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of oligodendrocyte progenitor proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

negative regulation of immune response

1 reference

8 April 2019

Src-family kinases in B-cell development and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

positive regulation of neuron projection development

1 reference

8 April 2019

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

peptidyl-tyrosine phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

signal transduction

1 reference

8 April 2019

G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

innate immune response

neuron projection development

2 references

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948

signal transduction

1 reference

31 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948

central nervous system development

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P07948

1 reference

31 January 2017

inflammatory response

positive regulation of protein phosphorylation

2 references

IGI

1 reference

8 April 2019

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

tolerance induction to self antigen

IGI

Src-family kinases in B-cell development and signaling

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

cellular response to DNA damage stimulus

Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

transmembrane receptor protein tyrosine kinase signaling pathway

positive regulation of phosphatidylinositol 3-kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

cell differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

positive regulation of Ras protein signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

1 reference

8 April 2019

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

1 reference

8 April 2019

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07948

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7906

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

5710

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

6044

English

tyrosine-protein kinase, active site

17 August 2016

has part(s)

1 reference

SH3 domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Tyrosine-protein kinase Lyn, SH2 domain

1 reference

Tyrosine-protein kinase Lyn, SH3 domain

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016