Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' (Q24632192)

7

1 reference

ORCID Public Data File 2021

author name string

Aron M Levin

1

0 references

Darren L Bates

2

0 references

Aaron M Ring

3

0 references

Carsten Krieg

4

0 references

Jack T Lin

5

0 references

Leon Su

6

0 references

Miro E Raeber

8

0 references

Gregory R Bowman

9

0 references

Paul Novick

10

0 references

Vijay S Pande

11

0 references

C Garrison Fathman

12

0 references

K Christopher Garcia

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

14

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language of work or name

English

0 references

publication date

26 April 2012

0 references

published in

Nature

0 references

volume

484

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issue

7395

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page(s)

529-33

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

The solution structure of the F42A mutant of human interleukin 2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Phasercrystallographic software

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Coot: model-building tools for molecular graphics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

PHENIX: building new software for automated crystallographic structure determination

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

7 April 2017

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Cloning of the gamma chain of the human IL-2 receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

New insights into the regulation of T cells by gamma(c) family cytokines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Isolating and engineering human antibodies using yeast surface display

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Hot-spot mimicry of a cytokine receptor by a small molecule

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Yeast surface display for screening combinatorial polypeptide libraries

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Cloning, sequence and expression of human interleukin-2 receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Interleukin-2: inception, impact, and implications

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Molecular cloning of cDNA encoding human interleukin-2 receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338870

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

30 May 2018

1 reference

Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors

21 January 2018

1 reference

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

21 January 2018

1 reference

Inference of macromolecular assemblies from crystalline state

21 January 2018

1 reference

Binding of small molecules to an adaptive protein-protein interface

21 January 2018

1 reference

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

21 January 2018

1 reference

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

21 January 2018

1 reference

P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.

21 January 2018

1 reference

Canonical dynamics: Equilibrium phase-space distributions

21 January 2018

1 reference

Using generalized ensemble simulations and Markov state models to identify conformational states

21 January 2018

1 reference

Progress and challenges in the automated construction of Markov state models for full protein systems

21 January 2018

1 reference

Network models for molecular kinetics and their initial applications to human health

21 January 2018

1 reference

Transition networks for modeling the kinetics of conformational change in macromolecules

21 January 2018

1 reference

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22446627

12 December 2020

inferred from PubMed ID database lookup

Comparative protein structure modeling using Modeller

1 reference

7 January 2021

Unraveling the structure of IL-2

1 reference

7 January 2021

The structure of interleukin-2 complexed with its alpha receptor

1 reference

7 January 2021

A smooth particle mesh Ewald method

1 reference

7 January 2021

Identifiers

DOI

10.1038/NATURE10975

1 reference

Dimensions Publication ID

1036269489

0 references

1 reference

1 reference

PubMed publication ID

22446627

1 reference