The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling (Q24629152)

1

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O Foreman

2

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S L Perkins

3

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T E Witzig

4

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R R Miles

5

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J van Deursen

6

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P J Galardy

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

7

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language of work or name

English

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publication date

September 2010

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published in

Leukemia

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volume

24

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issue

9

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page(s)

1641-55

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cites work

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation

7 April 2017

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Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis

27 September 2017

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beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

27 September 2017

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TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

27 September 2017

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Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

27 September 2017

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Frequent inactivation of A20 in B-cell lymphomas

27 September 2017

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TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

27 September 2017

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The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

27 September 2017

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Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

27 September 2017

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Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis

27 September 2017

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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

27 September 2017

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Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

27 September 2017

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PGP9.5 methylation in diffuse-type gastric cancer

27 September 2017

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27 September 2017

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

27 September 2017

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The Akt-mTOR tango and its relevance to cancer

27 September 2017

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PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma

27 September 2017

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Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells

27 September 2017

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

27 September 2017

1 reference

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

27 September 2017

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Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

27 September 2017

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Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

27 September 2017

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

27 September 2017

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27 September 2017

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Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues

27 September 2017

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c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells.

27 September 2017

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PGP9.5 as a candidate tumor marker for non-small-cell lung cancer

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Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells

27 September 2017

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Bethesda proposals for classification of lymphoid neoplasms in mice

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The American Burkitt's Lymphoma Registry: eight years' experience

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Identifiers

DOI

10.1038/LEU.2010.138

1 reference

Dimensions Publication ID

1039396642

0 references

Fatcat ID

release_7o6tpmcsdvc6fen7kwuclrfotm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7o6tpmcsdvc6fen7kwuclrfotm

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

20574456

1 reference