Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes (Q24629052)

3

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Gino Salituro

5

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Sang Ho Lee

7

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Maryann Powles

8

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Corey Miller

11

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Cai Li

15

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Sheo B. Singh

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Christine C. Chung

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Bindhu V. Karanam

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Kenneth P. Ellsworth

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Michael E. Lassman

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Robert W. Myers

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Michael R. Tota

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

Bei B. Zhang

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

26 November 2024

language of work or name

English

0 references

publication date

29 March 2011

0 references

9 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

full work available at URL

26 November 2024

https://europepmc.org/articles/pmc3069196?pdf=render

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

https://europepmc.org/articles/PMC3069196

26 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

https://europepmc.org/articles/PMC3069196?pdf=render

26 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

https://doi.org/10.1073/pnas.1002588108

26 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21389266

https://pnas.org/doi/pdf/10.1073/pnas.1002588108

26 November 2024

1 reference

DOI

10.1073/PNAS.1002588108

https://api.crossref.org/works/10.1073/PNAS.1002588108

Proceedings of the National Academy of Sciences of the United States of America

26 November 2024

published in

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volume

108

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issue

13

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page(s)

5378-83

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cites work

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

The role of the carnitine system in human metabolism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006.

27 September 2017

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

The Anorexigenic Fatty Acid Synthase Inhibitor, C75, Is a Nonspecific Neuronal Activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Essentiality of FASII pathway for Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Characterization of fatty acid synthase activity using scintillation proximity

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069196

Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

28 November 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.1002588108

Fatty acid synthesis and PPARalpha hand in hand

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21389266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1002588108

1 reference

ADS bibcode

2011PNAS..108.5378W

0 references

1 reference

1 reference

1 reference