Mechanism of action and inhibition of dehydrosqualene synthase (Q24628816)

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16 January 2020

title

Mechanism of action and inhibition of dehydrosqualene synthase (English)

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16 January 2020

8

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16 January 2020

9

Andrew H-J Wang

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16 January 2020

7

Tzu-Ping Ko

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16 January 2020

10

Eric Oldfield

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16 January 2020

author name string

Fu-Yang Lin

1

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16 January 2020

Chia-I Liu

2

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16 January 2020

Yi-Liang Liu

3

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16 January 2020

Yonghui Zhang

4

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16 January 2020

Ke Wang

5

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16 January 2020

Wen-Yih Jeng

6

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16 January 2020

language of work or name

English

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publication date

23 November 2010

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16 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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volume

107

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16 January 2020

issue

50

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16 January 2020

page(s)

21337-21342

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A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

16 January 2020

cites work

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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

7 April 2017

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Structure of limonene synthase, a simple model for terpenoid cyclase catalysis

7 April 2017

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Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

7 April 2017

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Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis

7 April 2017

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Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase

7 April 2017

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Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis

7 April 2017

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Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

7 April 2017

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

7 April 2017

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Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase

7 April 2017

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The Jpred 3 secondary structure prediction server

7 April 2017

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Golden Rice--five years on the road--five years to go?

7 April 2017

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Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus

27 September 2017

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In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi

27 September 2017

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GENES AND ENZYMES OF CAROTENOID BIOSYNTHESIS IN PLANTS.

27 September 2017

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Evolution of a pathway to novel long-chain carotenoids

27 September 2017

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Scoring residue conservation

27 September 2017

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A database and tools for 3-D protein structure comparison and alignment using the Combinatorial Extension (CE) algorithm.

27 September 2017

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In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.

27 September 2017

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Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

30 May 2018

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Phenoxypropylamines: a new series of squalene synthase inhibitors

30 May 2018

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Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene

30 May 2018

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Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors

21 January 2018

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Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope

21 January 2018

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Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs

21 January 2018

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Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes

21 January 2018

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Chemistry. Roots of biosynthetic diversity

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21098670

12 December 2020

inferred from PubMed ID database lookup

Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21098670

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1010907107

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16 January 2020

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24 November 2022

mapped directly with Wikidata item

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16 January 2020

PubMed publication ID

21098670

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