A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target (Q24623736)

1

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Esther Orozco

9

object named as

Esther Orozco

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James H McKerrow

15

object named as

James H McKerrow

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author name string

Derek Parsonage

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Rosa M Andrade

3

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Chen He

4

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Ken Hirata

6

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Steven Chen

7

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Guillermina García-Rivera

8

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Máximo B Martínez

10

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Shamila S Gunatilleke

11

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Amy M Barrios

12

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Michelle R Arkin

13

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Leslie B Poole

14

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Sharon L Reed

Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects

16

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language of work or name

English

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publication date

June 2012

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published in

Nature Medicine

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volume

18

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issue

6

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page(s)

956-60

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cites work

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A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

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Characterization of Saccharomyces cerevisiae Ras1p and chimaeric constructs of Ras proteins reveals the hypervariable region and farnesylation as critical elements in the adenylyl cyclase signaling pathway

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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

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The importance of glutathione in human disease

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Two atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine and iron reduction, and metronidazole activation in the enteric protozoan Entamoeba histolytica

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A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target

27 September 2017

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Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia

27 September 2017

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Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.

27 September 2017

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Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

27 September 2017

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Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model

27 September 2017

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The 29-kilodalton thiol-dependent peroxidase of Entamoeba histolytica is a factor involved in pathogenesis and survival of the parasite during oxidative stress.

27 September 2017

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Thioredoxin and related molecules--from biology to health and disease

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Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo

27 September 2017

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The diversity and evolution of thioredoxin reductase: new perspectives

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The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4 T cells

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Protein electrophoretic mobility shift assay to monitor redox state of thioredoxin in cells

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Effect of calcium antagonists, calcium channel blockers and calmodulin inhibitors on the growth and encystation of Entamoeba histolytica and E. invadens

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Thioredoxin reductase two modes of catalysis have evolved

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Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase

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12 December 2020

Application of a single-plasmid vector for mutagenesis and high-level expression of thioredoxin reductase and its use to examine flavin cofactor incorporation

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12 December 2020

Involvement of superoxide dismutase and pyruvate:ferredoxin oxidoreductase in mechanisms of metronidazole resistance in Entamoeba histolytica

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Transcriptomic comparison of two Entamoeba histolytica strains with defined virulence phenotypes identifies new virulence factor candidates and key differences in the expression patterns of cysteine proteases, lectin light chains, and calmodulin

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12 December 2020

Identifiers

DOI

10.1038/NM.2758

1 reference

Dimensions Publication ID

1037928183

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1 reference

1 reference

PubMed publication ID

22610278

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