Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity (Q24617126)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286 AND SRC:MED&resulttype=core&format=json

6 February 2020

title

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity (English)

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2

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John H Griffin

17

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Martin Hauer-Jensen

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author name string

Hartmut Geiger

1

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Edward J Kerschen

3

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Kalpana J Nattamai

4

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Irene Hernandez

5

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Hai Po H Liang

6

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Jose Á Fernández

7

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Jose A Cancelas

8

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Marnie A Ryan

9

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Olga Kustikova

10

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Qiang Fu

12

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Junru Wang

13

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Louis M Fink

14

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Karl-Uwe Petersen

15

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Daohong Zhou

16

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Christopher Baum

18

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Hartmut Weiler

19

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Axel Schambach

11

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language of work or name

English

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publication date

1 July 2012

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6 February 2020

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volume

18

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issue

7

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6 February 2020

page(s)

1123-1129

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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state

6 February 2020

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The cytoprotective protein C pathway

7 April 2017

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Solulin increases clot stability in whole blood from humans and dogs with hemophilia

7 April 2017

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Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis

27 September 2017

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Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

27 September 2017

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The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model

27 September 2017

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27 September 2017

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Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

27 September 2017

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Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

27 September 2017

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Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes

27 September 2017

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Regulation of inflammation by the protein C system

27 September 2017

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Extracellular histones are major mediators of death in sepsis

27 September 2017

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Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis

27 September 2017

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Determination of sample sizes for demonstrating efficacy of radiation countermeasures

27 September 2017

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Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

27 September 2017

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An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

27 September 2017

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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

27 September 2017

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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

27 September 2017

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Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

27 September 2017

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Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

27 September 2017

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27 September 2017

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Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells

27 September 2017

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Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway

27 September 2017

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27 September 2017

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Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy

27 September 2017

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Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation

27 September 2017

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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

27 September 2017

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Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

30 May 2018

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30 May 2018

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30 May 2018

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Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

30 May 2018

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Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.

19 June 2018

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28 November 2018

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Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response

28 November 2018

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Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium

28 November 2018

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Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

28 November 2018

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The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy.

28 November 2018

1 reference

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Role of the thrombin receptor in development and evidence for a second receptor.

28 November 2018

1 reference

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Characterization of a mouse model for thrombomodulin deficiency

28 November 2018

1 reference

12 December 2020

Mouse models of thrombosis: thrombomodulin

1 reference

12 December 2020

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

1 reference

12 December 2020

Optimal interfraction interval to minimize small bowel radiation injury in treatment regimens with two fractions per day: an experimental study in a rat model

1 reference

12 December 2020

Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation

1 reference

12 December 2020

Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates

1 reference

12 December 2020

Immunohistologic labeling of murine endothelium

1 reference

12 December 2020

Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus

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12 December 2020

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay

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12 December 2020

Phase I study of Solulin, a novel recombinant soluble human thrombomodulin analogue

1 reference

12 December 2020

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C

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12 December 2020

Recombinant soluble human thrombomodulin: a randomized, blinded assessment of prevention of venous thrombosis and effects on hemostatic parameters in a rat model

1 reference

12 December 2020

Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation

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12 December 2020

Identifiers

DOI

10.1038/NM.2813

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

1001141303

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Fatcat ID

release_mekxjmzajfeh3mv575oe5ld2vq

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Fatcat

https://api.fatcat.wiki/v0/release/mekxjmzajfeh3mv575oe5ld2vq

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22729286 AND SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

22729286

1 reference

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