Dual Inhibitor AEE788 Reduces Tumor Growth in Preclinical Models of Medulloblastoma (Q24615472)

5

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Riccardo Riccardi

7

object named as

Riccardo Riccardi

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Daniela Meco

object named as

Daniela Meco

1

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author name string

Tiziana Servidei

2

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Enrica Martinelli

4

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Chiara de Waure

6

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language of work or name

English

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publication date

2010

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published in

Translational Oncology

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Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

Crossref

volume

3

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issue

5

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page(s)

326-35

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cites work

1 reference

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The biology of VEGF and its receptors

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A perivascular niche for brain tumor stem cells

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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

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HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy

7 April 2017

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AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer

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Targeting vascular endothelial growth factor receptor in thyroid cancer: the intracellular and extracellular implications

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Kinome profiling in pediatric brain tumors as a new approach for target discovery

27 September 2017

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Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo

27 September 2017

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Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib

27 September 2017

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Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay

27 September 2017

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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy

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Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

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Functional VEGF and VEGF receptors are expressed in human medulloblastomas

27 September 2017

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Angiogenesis in brain tumours

27 September 2017

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Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with NVP-AEE788 for the treatment of aggressive follicular thyroid cancer

27 September 2017

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ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells

27 September 2017

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Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.

27 September 2017

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AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity

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Medulloblastoma: signalling a change in treatment

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Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma

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27 September 2017

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Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology

27 September 2017

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Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma.

27 September 2017

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Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model.

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Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model

28 November 2018

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https://pubmed.ncbi.nlm.nih.gov/20885895