Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization (Q24603527)

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17 November 2019

title

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization (English)

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17 November 2019

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7

Arndt Borkhardt

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17 November 2019

author name string

Bernd B Zeisig

1

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17 November 2019

María-Paz García-Cuéllar

3

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17 November 2019

Silke Schreiner

4

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17 November 2019

Mary-Ellen Martin

5

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17 November 2019

Uta Fuchs

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17 November 2019

Sumit K Chanda

8

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17 November 2019

John Walker

9

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17 November 2019

Richard Soden

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17 November 2019

Jay L Hess

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17 November 2019

Robert K Slany

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17 November 2019

language of work or name

English

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publication date

1 January 2004

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Molecular and Cellular Biology

17 November 2019

published in

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17 November 2019

volume

24

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issue

2

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17 November 2019

page(s)

617-628

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Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

17 November 2019

cites work

1 reference

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MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

7 April 2017

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The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

7 April 2017

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MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

7 April 2017

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HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells

7 April 2017

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Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice

7 April 2017

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

7 April 2017

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

7 April 2017

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Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice

7 April 2017

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

7 April 2017

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

7 April 2017

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MLL targets SET domain methyltransferase activity to Hox gene promoters

7 April 2017

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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

7 April 2017

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Altered Hox expression and segmental identity in Mll-mutant mice

7 April 2017

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Transcriptional activation is a key function encoded by MLL fusion partners

7 April 2017

1 reference

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Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

27 September 2017

1 reference

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Common mechanism for oncogenic activation of MLL by forkhead family proteins

27 September 2017

1 reference

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HOX and non-HOX homeobox genes in leukemic hematopoiesis

27 September 2017

1 reference

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The roles of FLT3 in hematopoiesis and leukemia

27 September 2017

1 reference

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Core-binding factors in haematopoiesis and leukaemia

27 September 2017

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

27 September 2017

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The role of MLL in hematopoiesis and leukemia

27 September 2017

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The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

27 September 2017

1 reference

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The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

27 September 2017

1 reference

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Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

27 September 2017

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

27 September 2017

1 reference

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Translocations of the RARalpha gene in acute promyelocytic leukemia

27 September 2017

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Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

27 September 2017

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

27 September 2017

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Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

27 September 2017

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27 September 2017

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Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

27 September 2017

1 reference

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Mll rearrangements in haematological malignancies: lessons from clinical and biological studies

27 September 2017

1 reference

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MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

27 September 2017

1 reference

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

27 September 2017

1 reference

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Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

Defects in yolk sac hematopoiesis in Mll-null embryos.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=343796

Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1

28 November 2018

1 reference

12 December 2020

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

12 December 2020

Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement

1 reference

12 December 2020

The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator

1 reference

12 December 2020

10.1128/MCB.24.2.617-628.2004

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14701735 AND SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14701735 AND SRC:MED&resulttype=core&format=json

17 November 2019

PubMed publication ID

14701735

2 references