Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na (Q24599447)

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29 January 2020

title

Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na (English)

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5

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Agnes Yong

10

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Phillip Scheinberg

13

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author name string

Matthew J Olnes

1

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Aarthie Shenoy

2

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Barbara Weinstein

3

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Loretta Pfannes

4

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Zachary Tucker

6

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Xin Tian

7

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Minjung Kwak

8

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Francois Wilhelm

9

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Irina Maric

11

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Manoj Maniar

12

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Jerome Groopman

14

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Neal S Young

15

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Elaine M Sloand

16

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language of work or name

English

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publication date

21 April 2012

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volume

36

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issue

8

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page(s)

982-989

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Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na

29 January 2020

cites work

1 reference

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

24 March 2017

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International scoring system for evaluating prognosis in myelodysplastic syndromes

24 March 2017

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Targeting immune dysregulation in myelodysplastic syndromes

24 March 2017

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Preclinical pharmacokinetics and in vitro activity of ON 01910.Na, a novel anti-cancer agent

27 September 2017

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Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells

27 September 2017

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Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells

27 September 2017

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Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors.

27 September 2017

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CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins

27 September 2017

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Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor

27 September 2017

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Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome

27 September 2017

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Efficacy of lenalidomide in myelodysplastic syndromes

27 September 2017

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Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program.

27 September 2017

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Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate ON 01910.Na, a mitotic progression modulator, in human plasma

27 September 2017

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Design and analysis of phase I clinical trials

30 May 2018

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Efficacy and safety of lenalidomide in intermediate-2 or high-risk myelodysplastic syndromes with 5q deletion: results of a phase 2 study

30 May 2018

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Myelodysplastic syndromes

28 November 2018

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Expression of cyclins D1, D2, and D3 and Ki-67 in Leukemia.

28 November 2018

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Molecular profiling of CD34 cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML.

28 November 2018

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Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities.

28 November 2018

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Involvement of cyclin D1 and E2F1 in intramedullary apoptosis in myelodysplastic syndromes.

28 November 2018

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Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase

28 November 2018

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Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation

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Cytogenetic abnormalities in paroxysmal nocturnal haemoglobinuria usually occur in haematopoietic cells that are glycosylphosphatidylinositol‐anchored protein (GPI‐AP) positive

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12 December 2020

Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q

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Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia

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Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes

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New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients

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Cell cycle and apoptosis regulatory gene expression in the bone marrow of patients with de novo myelodysplastic syndromes (MDS)

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Identifiers

DOI

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29 January 2020

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29 January 2020

PubMed publication ID

22524974

1 reference

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