A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway (Q24599024)

16

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Gary D. Bader

object named as

Gary D Bader

14

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author name string

Rajesh Raju

1

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Lavanya Balakrishnan

2

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Vishalakshi Nanjappa

3

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Mitali Bhattacharjee

4

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Derese Getnet

5

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Babylakshmi Muthusamy

6

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Joji Kurian Thomas

7

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Jyoti Sharma

8

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B Abdul Rahiman

9

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H C Harsha

10

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Subramanian Shankar

11

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T S Keshava Prasad

12

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S Sujatha Mohan

13

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Mohan R Wani

NetPath: a public resource of curated signal transduction pathways

15

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language of work or name

English

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publication date

2011

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published in

Database

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volume

2011

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issue

0

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page(s)

bar021

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cites work

1 reference

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Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts

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Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6

24 March 2017

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24 March 2017

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

24 March 2017

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

24 March 2017

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TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

24 March 2017

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

24 March 2017

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Structural and functional insights of RANKL-RANK interaction and signaling

24 March 2017

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Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution

24 March 2017

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Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

24 March 2017

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The BioPAX community standard for pathway data sharing

24 March 2017

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Catalytic properties of ADAM19

24 March 2017

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24 March 2017

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

24 March 2017

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TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

24 March 2017

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Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival

24 March 2017

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Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

24 March 2017

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24 March 2017

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

7 April 2017

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7 April 2017

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7 April 2017

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Molecular interactions and data standardisation

7 April 2017

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27 September 2017

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Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis

27 September 2017

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Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling

27 September 2017

1 reference

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RANK, RANKL and osteoprotegerin in bone biology and disease.

27 September 2017

1 reference

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New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?

27 September 2017

1 reference

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The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo

27 September 2017

1 reference

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Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers.

27 September 2017

1 reference

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RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

27 September 2017

1 reference

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Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

27 September 2017

1 reference

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RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation

27 September 2017

1 reference

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27 September 2017

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Phosphoproteomic analysis of Her2/neu signaling and inhibition

27 September 2017

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A comprehensive map of the toll-like receptor signaling network

27 September 2017

1 reference

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Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

Identification of an alternatively spliced variant of Ca2 -promoted Ras inactivator as a possible regulator of RANKL shedding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

27 September 2017

1 reference

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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

Enhanced Effector and Memory CTL Responses Generated by Incorporation of Receptor Activator of NF-κB (RANK)/RANK Ligand Costimulatory Molecules into Dendritic Cell Immunogens Expressing a Human Tumor-Specific Antigen

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

RANK ligand is a prerequisite for cancer-associated osteolytic lesions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

27 September 2017

1 reference

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TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

VISIBIOweb: visualization and layout services for BioPAX pathway models

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170171

RANK signals from CD4( )3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

30 May 2018

1 reference

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JNK/c-Jun Signaling Mediates an Anti-Apoptotic Effect of RANKL in Osteoclasts

30 May 2018

1 reference

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A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".

28 November 2018

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Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

28 November 2018

1 reference

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NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1

28 November 2018

1 reference

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Tumour cells produce receptor activator of NF-kappaB ligand (RANKL) in skeletal metastases

28 November 2018

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Long-lived immature dendritic cells mediated by TRANCE-RANK interaction

28 November 2018

1 reference

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Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase

28 November 2018

1 reference

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Osteoclast lineage commitment of bone marrow precursors through expression of membrane-bound TRANCE.

28 November 2018

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Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues.

28 November 2018

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Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand

28 November 2018

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12 December 2020

Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis

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12 December 2020

JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms

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12 December 2020

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

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12 December 2020

Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)

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Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8 T cell memory responses in HIV-1-infected and HIV-1-uninfected indivi

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12 December 2020

A comprehensive map of the IL-1R signalling network.

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Crossref

https://api.crossref.org/works/10.1093/DATABASE/BAR021

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1093/DATABASE/BAR021

1 reference

1 reference

1 reference

PubMed publication ID

21742767

1 reference