The retinoblastoma protein is phosphorylated on multiple sites by human cdc2 (Q24564605)

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17 November 2022

K. J. Buchkovich

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17 November 2022

D. R. Marshak

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17 November 2022

C. W. Anderson

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17 November 2022

E. Harlow

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full work available at URL

17 November 2022

language of work or name

English

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publication date

December 1991

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1756735/?tool=EBI

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17 November 2022

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open access

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https://europepmc.org/articles/PMC453181

17 November 2022

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https://europepmc.org/articles/PMC453181?pdf=render

17 November 2022

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Portable Document Format

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open access

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https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002/j.1460-2075.1991.tb05006.x

17 November 2022

1 reference

10.1002/J.1460-2075.1991.TB05006.X

Crossref

DOI

https://api.crossref.org/works/10.1002/J.1460-2075.1991.TB05006.X

http://onlinelibrary.wiley.com/wol1/doi/10.1002/j.1460-2075.1991.tb05006.x/fullpdf

17 November 2022

1 reference

10.1002/J.1460-2075.1991.TB05006.X

Crossref

DOI

https://api.crossref.org/works/10.1002/J.1460-2075.1991.TB05006.X

17 November 2022

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10

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issue

13

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page(s)

4279-90

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cites work

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen

1 reference

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Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product

24 March 2017

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The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations

24 March 2017

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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

24 March 2017

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Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

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24 March 2017

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

7 April 2017

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

7 April 2017

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

7 April 2017

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Universal control mechanism regulating onset of M-phase

7 April 2017

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The E2F transcription factor is a cellular target for the RB protein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

27 September 2017

1 reference

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Dominoes and clocks: the union of two views of the cell cycle

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Mammalian growth-associated H1 histone kinase: a homolog of cdc2 /CDC28 protein kinases controlling mitotic entry in yeast and frog cells

27 September 2017

1 reference

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Control of the higher eukaryote cell cycle by p34cdc2 homologues

27 September 2017

1 reference

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Cellular targets for transformation by the adenovirus E1A proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Substrates for p34cdc2: in vivo veritas?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Cyclin is a component of maturation-promoting factor from Xenopus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Structural evidence for the authenticity of the human retinoblastoma gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Human retinoblastoma susceptibility gene: cloning, identification, and sequence

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Inactivation of the retinoblastoma susceptibility gene in human breast cancers

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=453181

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

28 November 2018

1 reference

12 December 2020

Phosphorylation of hepatic ribosomal protein S6 on 80 and 40 S ribosomes. Primary structure of S6 in the region of the major phosphorylation sites for cAMP-dependent protein kinases

1 reference

12 December 2020

Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1 reference

12 December 2020

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

1 reference

12 December 2020

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1 reference

12 December 2020

Structural rearrangement of the retinoblastoma gene in human breast carcinoma

1 reference

12 December 2020

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2

1 reference

12 December 2020

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung

1 reference

12 December 2020

cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF

1 reference

12 December 2020

11 Synthetic peptide substrates for casein kinase II

1 reference

12 December 2020

Starting and stopping

1 reference

12 December 2020

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1 reference

12 December 2020

Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF

1 reference

12 December 2020

Point mutational inactivation of the retinoblastoma antioncogene

1 reference

12 December 2020

The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues

1 reference

12 December 2020

10.1002/J.1460-2075.1991.TB05006.X

Identifiers

DOI

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1756735

17 November 2022

PMC publication ID

453181

0 references