The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum (Q24534370)

4 July 2017

title

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum (English)

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4 July 2017

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Tin-Wein Yu

1

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4 July 2017

Linquan Bai

2

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4 July 2017

Dorothee Clade

3

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4 July 2017

Dietmar Hoffmann

4

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4 July 2017

Sabine Toelzer

5

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4 July 2017

Khue Q Trinh

6

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4 July 2017

Jun Xu

7

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4 July 2017

Steven J Moss

8

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4 July 2017

Eckhard Leistner

9

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4 July 2017

Heinz G Floss

10

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4 July 2017

language of work or name

English

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publication date

1 June 2002

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Proceedings of the National Academy of Sciences of the United States of America

4 July 2017

published in

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4 July 2017

volume

99

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4 July 2017

issue

12

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4 July 2017

page(s)

7968-7973

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Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891

4 July 2017

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27 September 2017

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Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

27 September 2017

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27 September 2017

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27 September 2017

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Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens

27 September 2017

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27 September 2017

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Complete nucleotide sequence of the Streptomyces lividans plasmid pIJ101 and correlation of the sequence with genetic properties

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.

27 September 2017

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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21 January 2018

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The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates

21 January 2018

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Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892.

21 January 2018

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Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis

21 January 2018

1 reference

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The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units

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cDNA cloning, substrate specificity and expression study of tobacco caffeoyl-CoA 3-O-methyltransferase, a lignin biosynthetic enzyme

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Biosynthetic origin of the C2 units of geldanamycin and distribution of label from D-[6-13C]glucose

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12 December 2020

Biosynthetic origin of aminobenzenoid nucleus (C7N-unit) of ansamitocin, a group of novel maytansinoid antibiotics

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Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B

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Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei

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Antitumor principles in mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3

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Chemical modification of ansamitocins. III. Synthesis and biological effects of 3-acyl esters of maytansinol

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Tumor inhibitors. 124. Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids

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Glucose-fructose oxidoreductase, a periplasmic enzyme of Zymomonas mobilis, is active in its precursor form

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1073/PNAS.092697199

1 reference

release_di4elfdlwregfbu5xo6oa6d2v4

4 July 2017

0 references

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PMC publication ID

123004

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4 July 2017

1 reference