WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate (Q24530650)

Alan R Prescott

5

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Dario Alessi

Dario R Alessi

8

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Alberto C Vitari

1

Alberto C Vitari

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Nick Morrice

4

Nick Morrice

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author name string

Barry J Collins

3

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Anne Phelan

6

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Sian Humphreys

14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

7

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language of work or name

English

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publication date

15 February 2004

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published in

Biochemical Journal

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volume

378

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issue

Pt 1

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page(s)

257-68

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cites work

1 reference

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Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

24 March 2017

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A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

24 March 2017

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MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

24 March 2017

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Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

24 March 2017

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Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

24 March 2017

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Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

27 September 2017

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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

24 March 2017

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

24 March 2017

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Mechanism of activation of protein kinase B by insulin and IGF-1

24 March 2017

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WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

24 March 2017

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Human hypertension caused by mutations in WNK kinases

24 March 2017

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Synthesis and function of 3-phosphorylated inositol lipids

24 March 2017

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

24 March 2017

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

24 March 2017

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Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

24 March 2017

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24 March 2017

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Cyclic nucleotide-dependent protein kinases

24 March 2017

1 reference

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WNK kinases regulate thiazide-sensitive Na-Cl cotransport

24 March 2017

1 reference

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WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

24 March 2017

1 reference

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

24 March 2017

1 reference

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PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

24 March 2017

1 reference

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

7 April 2017

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In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

7 April 2017

1 reference

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Unravelling the activation mechanisms of protein kinase B/Akt

27 September 2017

1 reference

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WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia

27 September 2017

1 reference

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Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na( ) transport

27 September 2017

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Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

27 September 2017

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Ten years of protein kinase B signalling: a hard Akt to follow

27 September 2017

1 reference

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PKB/AKT: functional insights from genetic models

27 September 2017

1 reference

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GSK3 takes centre stage more than 20 years after its discovery

27 September 2017

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A motif-based profile scanning approach for genome-wide prediction of signaling pathways

27 September 2017

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Cellular signaling: pivoting around PDK-1.

27 September 2017

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Role of S6 phosphorylation and S6 kinase in cell growth

27 September 2017

1 reference

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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

27 September 2017

1 reference

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223938

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223938

The hormonal control of glycogen metabolism: The amino acid sequence at the phosphorylation site of protein phosphatase inhibitor-1

27 September 2017

1 reference

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Transcriptional regulation by cyclic AMP.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1223938

Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture

30 May 2018

1 reference

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14611643

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14611643