Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins (Q24530571)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

review article

1 reference

title

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

author name string

K Nakayama

series ordinal

1

0 references

language of work or name

English

0 references

publication date

1 November 1997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

number of pages

11

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inferred from page(s)

published in

Biochemical Journal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

volume

327 ( Pt 3)

1 reference

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11 November 2019

page(s)

625-635

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells

11 November 2019

cites work

1 reference

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The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

24 March 2017

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Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4( ) cell lines

24 March 2017

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Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform

24 March 2017

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Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease

24 March 2017

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Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4 T lymphocytes

24 March 2017

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Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

24 March 2017

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PC8 [corrected], a new member of the convertase family

24 March 2017

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Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin

24 March 2017

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Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

24 March 2017

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Site-directed mutagenesis and the role of the oxyanion hole in subtilisin

24 March 2017

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Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein

24 March 2017

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Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site

24 March 2017

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Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease

24 March 2017

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

24 March 2017

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Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo

24 March 2017

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Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2 -dependent serine protease

24 March 2017

1 reference

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Furin-dependent intracellular activation of the human stromelysin-3 zymogen

24 March 2017

1 reference

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Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms

24 March 2017

1 reference

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Processing of transforming growth factor beta 1 precursor by human furin convertase

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Isolation, purification, and characterization of gamma-lipotropic hormone from sheep pituitary glands

24 March 2017

1 reference

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Insulin biosynthesis: evidence for a precursor

24 March 2017

1 reference

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The molecular basis of blood coagulation

24 March 2017

1 reference

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Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases

24 March 2017

1 reference

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Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae

24 March 2017

1 reference

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Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

24 March 2017

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Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage

24 March 2017

1 reference

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Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2

24 March 2017

1 reference

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PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

24 March 2017

1 reference

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

24 March 2017

1 reference

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The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM)

24 March 2017

1 reference

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Intracellular proteolytic processing of the two-chain vitamin K-dependent coagulation factor X

24 March 2017

1 reference

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Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

24 March 2017

1 reference

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Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

24 March 2017

1 reference

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Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

24 March 2017

1 reference

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Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

24 March 2017

1 reference

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Proprotein-Processing Endoprotease Furin Controls Growth of Pancreatic β-Cells

7 April 2017

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Proprotein-processing endoprotease furin controls the growth and differentiation of gastric surface mucous cells

27 September 2017

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Comparative processing of bovine leukemia virus envelope glycoprotein gp72 by subtilisin/kexin-like mammalian convertases.

27 September 2017

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Localization of endogenous furin in cultured cell lines

27 September 2017

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Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail

27 September 2017

1 reference

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SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

27 September 2017

1 reference

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Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A alpha 20 Val --> Asp).

27 September 2017

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cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

27 September 2017

1 reference

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A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A is unable to process the precursor fusion glycoprotein of Newcastle disease virus.

27 September 2017

1 reference

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Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.

27 September 2017

1 reference

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Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

27 September 2017

1 reference

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cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

27 September 2017

1 reference

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Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases

27 September 2017

1 reference

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Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.

27 September 2017

1 reference

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Retrieval of TGN proteins from the cell surface requires endosomal acidification.

27 September 2017

1 reference

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A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1.

27 September 2017

1 reference

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Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.

27 September 2017

1 reference

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Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.

27 September 2017

1 reference

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An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Designing Subtilisin BPN' To Cleave Substrates Containing Dibasic Residues

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene

27 September 2017

1 reference

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Precursors to regulatory peptides: their proteolytic processing

27 September 2017

1 reference

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Enzymes required for yeast prohormone processing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

The molecular biology of influenza virus pathogenicity

27 September 2017

1 reference

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fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Haemophilia B: database of point mutations and short additions and deletions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Endopeptidases and prohormone processing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Mammalian subtilisins: the long-sought dibasic processing endoproteases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A and alphaviruses fails to cleave Sindbis virus glycoprotein PE2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Cloning and Functional Expression of a Novel Endoprotease Involved in Prohormone Processing at Dibasic Sites1

27 September 2017

1 reference

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Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

TGN38 and its orthologues: roles in post-TGN vesicle formation and maintenance of TGN morphology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Evidence for involvement of furin in cleavage and activation of diphtheria toxin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Sequence requirements for endoproteolytic processing of precursor proteins by furin: transfection and in vitro experiments.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Region specific expression of furin mRNA in the rat brain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Characterization of a secreted form of human furin endoprotease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Proteolytic processing is required for viral superantigen activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Calcium-dependent KEX2-like protease found in hepatic secretory vesicles converts proalbumin to albumin.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position -4.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Intracellular targeting and structural conservation of a prohormone-processing endoprotease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Intracellular processing of complement pro-C3 and proalbumin is inhibited by rat alpha 1-protease inhibitor variant (Met352----Arg) in transfected cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Arg15-Lys17-Arg18 turkey ovomucoid third domain inhibits human furin.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Furin-induced cleavage and activation of Shiga toxin

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Analysis of mutations in alleles of the fur gene from an endoprotease-deficient Chinese hamster ovary cell strain

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218878

Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin

29 November 2018

1 reference

12 December 2020

Furin has the proalbumin substrate specificity and serpin inhibitory properties of an in situ hepatic convertase

1 reference

12 December 2020

Cleavage of proalbumin peptides by furin reveals unexpected restrictions at the P2 and P'1 sites

1 reference

12 December 2020

The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase

1 reference

12 December 2020

Porcine proinsulin: characterization and amino acid sequence

1 reference

12 December 2020

A circulating variant of human proalbumin

1 reference

12 December 2020

Structure and properties of albumin Tokushima and its proteolytic processing by cathepsin B in vitro

1 reference

12 December 2020

Yeast KEX2 protease has the properties of a human proalbumin converting enzyme

1 reference

12 December 2020

Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells

1 reference

12 December 2020

The optimum Butterworth-Wiener filter for I-123 IMP brain SPECT

1 reference

12 December 2020

Modelling and engineering of enzyme/substrate interactions in subtilisin-like enzymes of unknown 3-dimensional structure

1 reference

12 December 2020

Immunocytochemical localization of prohormone convertases PC1/PC3 and PC2 in rat pancreatic islets

1 reference

12 December 2020

Selective processing of proalbumin determined by site-specific mutagenesis

1 reference

12 December 2020

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1 reference

12 December 2020

Sequence requirements for precursor cleavage within the constitutive secretory pathway

1 reference

12 December 2020

Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein

1 reference

12 December 2020

Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells

1 reference

12 December 2020

Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization

1 reference

12 December 2020

Purification and characterization of the prohormone convertase PC1(PC3)

1 reference

12 December 2020

Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

1 reference

12 December 2020

Design and synthesis of novel inhibitors of prohormone convertases

1 reference

12 December 2020

Distribution of the Kexin family proteases in pancreatic islets: PACE4C is specifically expressed in B cells of pancreatic islets

1 reference

12 December 2020

Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary

1 reference

12 December 2020

Processing of proendothelin-1 by human furin convertase

1 reference

12 December 2020

Processing of pro-PTHRP by the prohormone convertase, furin: effect on biological activity

1 reference

12 December 2020

Mutational analysis of the insulin-like growth factor I prohormone processing site

1 reference

12 December 2020

Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor

1 reference

12 December 2020

Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin

1 reference

12 December 2020

Peptidyl substrates containing unnatural amino acid at the P'1 position are potent inhibitors of prohormone convertases

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ3270625

2 references

Consolidated OpenCitations Corpus – April 2017

2669135

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

2669135

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9599222 AND SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

9599222

2 references

Consolidated OpenCitations Corpus – April 2017

2669135