Production of novel rapamycin analogs by precursor-directed biosynthesis (Q24522424)

2 July 2017

title

Production of novel rapamycin analogs by precursor-directed biosynthesis (English)

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2 July 2017

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Frank V Ritacco

1

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2 July 2017

Edmund I Graziani

2

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2 July 2017

Mia Y Summers

3

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2 July 2017

T Mark Zabriskie

4

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2 July 2017

Ker Yu

5

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2 July 2017

Valerie S Bernan

6

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2 July 2017

Guy T Carter

7

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2 July 2017

Michael Greenstein

8

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2 July 2017

language of work or name

English

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publication date

1 April 2005

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Applied and Environmental Microbiology

2 July 2017

published in

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2 July 2017

volume

71

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2 July 2017

issue

4

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2 July 2017

page(s)

1971-1976

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The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

2 July 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted in rapL , Encoding a Putative Lysine Cyclodeaminase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

New rapamycin derivatives by precursor-directed biosynthesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Bench to bedside: the development of rapamycin and its application to stent restenosis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Deletion of rapQONML from the rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin — Nucleotide Sequence Analysis, Disruption and Heterologous Expression of Rap P from Streptomyces Hygroscopicus

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1082568

Demethoxyrapamycin (AY-24,668),a new antifungal antibiotic

29 November 2018

1 reference

12 December 2020

Generation of Novel Rapamycin Structures by Microbial Manipulations

1 reference

12 December 2020

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

1 reference

12 December 2020

Manipulation of the C(22)-C(27) region of rapamycin: stability issues and biological implications

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12 December 2020

Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity

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12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

DOI

10.1128/AEM.71.4.1971-1976.2005

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2 July 2017

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