Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model (Q24338827)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24154541 AND SRC:MED&resulttype=core&format=json

28 February 2020

title

Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24154541 AND SRC:MED&resulttype=core&format=json

neurofibrillary tangle assembly

28 February 2020

main subject

1 reference

Gene Ontology release 2020-05-02

1 reference

GOA release 2020-03-11

negative regulation of amyloid-beta formation

1 reference

GOA release 2020-03-11

author

Gustavo Rodriguez

4

1 reference

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28 February 2020

2

Sonya B Dumanis

1 reference

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28 February 2020

Mary Jo Ladu

5

0 references

author name string

Wenjuan Zhao

1

1 reference

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28 February 2020

Irfan Y Tamboli

3

1 reference

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28 February 2020

Charbel E H Moussa

6

1 reference

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28 February 2020

G William Rebeck

7

1 reference

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28 February 2020

language of work or name

English

0 references

publication date

23 October 2013

1 reference

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28 February 2020

published in

Human Molecular Genetics

1 reference

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28 February 2020

volume

23

1 reference

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28 February 2020

issue

5

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28 February 2020

page(s)

1365-1375

1 reference

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

28 February 2020

cites work

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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7 April 2017

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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration

7 April 2017

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Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).

27 September 2017

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Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

27 September 2017

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Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.

27 September 2017

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Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex

27 September 2017

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Inflammation in the early stages of neurodegenerative pathology

27 September 2017

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

27 September 2017

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Alzheimer's disease: the challenge of the second century

27 September 2017

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The role of microglia in amyloid clearance from the AD brain

27 September 2017

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Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

27 September 2017

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Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization

27 September 2017

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Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

27 September 2017

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Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss

27 September 2017

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Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

27 September 2017

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The role of apolipoprotein E in Alzheimer's disease

27 September 2017

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Parkin promotes intracellular Abeta1-42 clearance

27 September 2017

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Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

27 September 2017

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Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

27 September 2017

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Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

27 September 2017

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Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain

27 September 2017

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Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

27 September 2017

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27 September 2017

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Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration

27 September 2017

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

27 September 2017

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

27 September 2017

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27 September 2017

Lysosomes in cell death

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Clearing the brain's amyloid cobwebs

27 September 2017

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Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease

27 September 2017

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Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein

27 September 2017

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Intraneuronal Abeta42 accumulation in human brain.

27 September 2017

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Apo E structure determines VLDL clearance and atherosclerosis risk in mice.

27 September 2017

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Specific regional transcription of apolipoprotein E in human brain neurons

27 September 2017

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Identification of two lysosomal membrane glycoproteins

27 September 2017

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The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

27 September 2017

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β‐Amyloid Peptides Increase the Binding and Internalization of Apolipoprotein E to Hippocampal Neurons

30 May 2018

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30 May 2018

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29 November 2018

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Scavenger receptor class B type I localizes to a late endosomal compartment

29 November 2018

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29 November 2018

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

29 November 2018

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29 November 2018

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Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

29 November 2018

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Significance of intracellular Abeta42 accumulation in Alzheimer's disease

29 November 2018

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Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology

29 November 2018

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Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor

29 November 2018

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

29 November 2018

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Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24154541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24154541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24154541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDT525

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24154541 AND SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24154541 AND SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

24154541

1 reference