C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling (Q24337647)

1 reference

Transcriptional and immune response regulator

1 reference

NOTCH regulated ankyrin repeat protein

1 reference

Notch signaling pathway

1 reference

neoplastic stem cells

1 reference

1 reference

Pingping Zhu

1

0 references

Yanying Wang

2

0 references

Ying Du

3

0 references

Lei He

4

0 references

Guanling Huang

5

0 references

Geng Zhang

6

0 references

Xinlong Yan

7

0 references

Zusen Fan

Creative Commons Attribution 4.0 International

8

0 references

language of work or name

English

0 references

publication date

2015

0 references

published in

Nature Communications

0 references

volume

6

0 references

page(s)

7122

0 references

copyright license

start time

19 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer

19 March 2017

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TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer

19 March 2017

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C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer

7 April 2017

1 reference

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TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer

19 March 2017

1 reference

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Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer

19 March 2017

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The canonical Notch signaling pathway: unfolding the activation mechanism

19 March 2017

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Notch signalling: a simple pathway becomes complex

7 April 2017

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Differential effects of targeting Notch receptors in a mouse model of liver cancer

7 April 2017

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WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner

27 September 2017

1 reference

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Wnt-Notch signalling crosstalk in development and disease.

27 September 2017

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TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074.

27 September 2017

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Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.

27 September 2017

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Self-renewal as a therapeutic target in human colorectal cancer.

27 September 2017

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1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit.

27 September 2017

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Clinical implications of cancer stem cell biology in hepatocellular carcinoma

27 September 2017

1 reference

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Cancer stem cells: current status and evolving complexities

27 September 2017

1 reference

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Functional genomic studies: insights into the pathogenesis of liver cancer.

27 September 2017

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HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells

27 September 2017

1 reference

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CD24 Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

27 September 2017

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Notch signalling in solid tumours: a little bit of everything but not all the time

27 September 2017

1 reference

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A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.

27 September 2017

1 reference

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Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

27 September 2017

1 reference

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CD13 is a therapeutic target in human liver cancer stem cells

27 September 2017

1 reference

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Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

27 September 2017

1 reference

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The therapeutic promise of the cancer stem cell concept

27 September 2017

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Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

27 September 2017

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Acquired copy number alterations in adult acute myeloid leukemia genomes

27 September 2017

1 reference

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Notch signaling: the core pathway and its posttranslational regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Identification and characterization of tumorigenic liver cancer stem/progenitor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4479500

Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

30 May 2018

1 reference

Prediction of disease-free survival in hepatocellular carcinoma by gene expression profiling

21 January 2018

1 reference

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

21 January 2018

1 reference

Unravelling cancer stem cell potential.

21 January 2018

1 reference

A critical role for notch signaling in the formation of cholangiocellular carcinomas

21 January 2018

1 reference

Constitutive Notch2 signaling induces hepatic tumors in mice

21 January 2018

1 reference

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

21 January 2018

1 reference

Investigation of copy-number variations of C8orf4 in hematological malignancies

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25985737

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS8122

1 reference

Dimensions Publication ID

ADS bibcode

2015NatCo...6.7122Z

0 references

1000753022

0 references

Fatcat ID

release_uirmghjzcfdidprpq3w4illrau

0 references

1 reference

1 reference

PubMed publication ID

25985737

1 reference