Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme (Q24337187)

GOA release 2020-03-11

DNA biosynthetic process

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GOA release 2020-03-11

author name string

Lambratu Rahman

1

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Donna Voeller

2

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Monzur Rahman

3

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Stan Lipkowitz

4

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Carmen Allegra

5

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J Carl Barrett

6

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Frederic J Kaye

7

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Maria Zajac-Kaye

The N-Terminal Domain of c-Myc Associates with α-Tubulin and Microtubules In Vivo and In Vitro

8

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language of work or name

English

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publication date

April 2004

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published in

Cancer Cell

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volume

5

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issue

4

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page(s)

341-51

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cites work

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Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication

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Mutagenicity of thymidine to cultured Chinese hamster cells

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Emerging roles for E2F: Beyond the G1/S transition and DNA replication

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Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

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Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

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Bromodeoxyuridine mutagenesis in mammalian cells is stimulated by thymidine and suppressed by deoxycytidine

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

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Transcriptional control elements and complex initiation pattern of the TATA-less bidirectional human thymidylate synthase promoter

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The regulation of E2F by pRB-family proteins

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Induction of apoptosis in fibroblasts by c-myc protein

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Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential

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The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments

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Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma

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The Rb/E2F pathway: expanding roles and emerging paradigms

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Regulation of cell proliferation by the E2F transcription factors

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Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites

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c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

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Predictive and prognostic markers in gastrointestinal cancers

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Sensitivity of a Mutator Gene in Chinese Hamster Ovary Cell to Deoxynucleoside Triphosphate Pool Alterations

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The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

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Disruption of Myc-tubulin interaction by hyperphosphorylation of c-Myc during mitosis or by constitutive hyperphosphorylation of mutant c-Myc in Burkitt's lymphoma

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Clinical significance of thymidylate synthase expression in bladder cancer

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Prognostic importance of thymidylate synthase expression in early breast cancer

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Thymidylate synthase and drug resistance

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E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

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The myc intron-binding polypeptide associates with RFX1 in vivo and binds to the major histocompatibility complex class II promoter region, to the hepatitis B virus enhancer, and to regulatory regions of several distinct viral genes

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Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

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New prognostic indicator for non-small-cell lung cancer, quantitation of thymidylate synthase by real-time reverse transcription polymerase chain reaction

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Enhanced expression of thymidylate synthase may be of prognostic importance in advanced cervical cancer

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Isolation and Characterization of Thymitaq (AG337) and 5-Fluoro-2-deoxyuridylate-resistant Mutants of Human Thymidylate Synthase from Ethyl Methanesulfonate-exposed Human Sarcoma HT1080 Cells

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Sibling rivalry in the E2F family

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The identification of thymidylate synthase peptide domains located in the interface region that bind thymidylate synthase mRNA.

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Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1

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Multiple members of the E2F transcription factor family are the products of oncogenes

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DNAase I encapsulated in liposomes can induce neoplastic transformation of Syrian hamster embryo cells in culture

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

release_borymegfxjcxzbjbacnl3wl54a

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/borymegfxjcxzbjbacnl3wl54a

24 November 2022

mapped directly with Wikidata item

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15093541

1 reference

Consolidated OpenCitations Corpus – April 2017