The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1 (Q24337165)

Ras homolog family member A

GOA release 2020-03-11

1 reference

Kinase suppressor of ras 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Anne-Claude Gingras

16

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Mitsuhiko Ikura

12

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Troy Ketela

13

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Oliver A Kent

Oliver A Kent

5

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Christopher B Marshall

Christopher B Marshall

11

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Robert Rottapel

Robert Rottapel

18

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Ming-Sound Tsao

Ming-Sound Tsao

17

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author name string

Jane Cullis

1

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David Meiri

2

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Maria Jose Sandi

3

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Nikolina Radulovich

4

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Mauricio Medrano

6

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Daphna Mokady

7

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Josee Normand

8

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Jose Larose

9

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Richard Marcotte

10

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Jason Moffat

14

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Benjamin G Neel

Tiam1 mutations in human renal-cell carcinomas

15

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language of work or name

English

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publication date

10 February 2014

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published in

Cancer Cell

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volume

25

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issue

2

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page(s)

181-95

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cites work

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KSR, a novel protein kinase required for RAS signal transduction

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The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

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ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.

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Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

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KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression

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KSR stimulates Raf-1 activity in a kinase-independent manner

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Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

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KSR modulates signal propagation within the MAPK cascade

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Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

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A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

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Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

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