Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain (Q24336240)

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N R Landau

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M E Lenburg

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D Trono

A human cell factor is essential for HIV-1 Rev action.

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language of work or name

English

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publication date

11 March 1994

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published in

Cell

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volume

76

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issue

5

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page(s)

853-64

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cites work

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Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

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Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4 cells: mechanism for persistence in AIDS.

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The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

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CD4: collaborator in immune recognition and HIV infection

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Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

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Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

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A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

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T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

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Molecular biology and function of CD4 and CD8

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Molecular Events Mediating T Cell Activation

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The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

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Expression and function of CD4 in a murine T-cell hybridoma

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Interaction between CD4 and class II MHC molecules mediates cell adhesion

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HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor

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The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

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Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts

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Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells

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Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

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Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting

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Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR

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Molecular Characterization of Human T-Cell Leukemia (Lymphotropic) Virus Type III in the Acquired Immune Deficiency Syndrome

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Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression

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Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

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Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4.

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Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.

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Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum

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Signal-dependent membrane protein trafficking in the endocytic pathway

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

8124721

1 reference

Consolidated OpenCitations Corpus – April 2017