Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells (Q24323987)

19 October 2023

Renato V Iozzo

5

Renato V

Iozzo

1 reference

19 October 2023

Atul Goyal

1

Atul

Goyal

1 reference

19 October 2023

Thomas Neill

series ordinal

2

author given names

Thomas

author last names

Neill

1 reference

19 October 2023

Rick T Owens

series ordinal

3

author given names

Rick T

author last names

Owens

1 reference

describes a project that uses

19 October 2023

language of work or name

English

0 references

publication date

February 2014

0 references

published in

Matrix Biology

0 references

volume

34

0 references

page(s)

46-54

0 references

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4080419/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4080419/fullTextXML

inferred from PubMed Central ID database lookup

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Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

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19 March 2017

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The biology of small leucine-rich proteoglycans in bone pathophysiology

19 March 2017

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Biological interplay between proteoglycans and their innate immune receptors in inflammation

19 March 2017

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19 March 2017

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

19 March 2017

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Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21

19 March 2017

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

19 March 2017

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Decorin is a biological ligand for the epidermal growth factor receptor

19 March 2017

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Decorin deficiency promotes hepatic carcinogenesis

7 April 2017

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Decorin has an appetite for endothelial cell autophagy

27 September 2017

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Extracellular matrix transcriptome dynamics in hepatocellular carcinoma

27 September 2017

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AMPK: a contextual oncogene or tumor suppressor?

27 September 2017

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Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels

27 September 2017

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Role of skeletal muscle proteoglycans during myogenesis

27 September 2017

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Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis.

27 September 2017

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Dichotomy of decorin activity on the insulin-like growth factor-I system

27 September 2017

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Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin expression is important for age-related changes in tendon structure and mechanical properties.

27 September 2017

1 reference

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Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear fact

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model

27 September 2017

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Decorin: a guardian from the matrix

27 September 2017

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Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice

27 September 2017

1 reference

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The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells

27 September 2017

1 reference

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Role of autophagy in angiogenesis in aortic endothelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast

27 September 2017

1 reference

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Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

The association of AMPK with ULK1 regulates autophagy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine‐rich proteoglycans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin is a novel antagonistic ligand of the Met receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Targeted disruption of ROCK1 causes insulin resistance in vivo.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

AMP-activated protein kinase and human cancer: cancer metabolism revisited

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

An antimetastatic role for decorin in breast cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Bcl-2 inhibition of autophagy: a new route to cancer?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin prevents metastatic spreading of breast cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Biologically active decorin is a monomer in solution.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

The role of decorin in collagen fibrillogenesis and skin homeostasis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin-mediated signal transduction in endothelial cells. Involvement of Akt/protein kinase B in up-regulation of p21(WAF1/CIP1) but not p27(KIP1).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Altered proteoglycan gene expression and the tumor stroma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

A central role for decorin during vertebrate convergent extension

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

A role for decorin in cutaneous wound healing and angiogenesis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene Peg3.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin deficiency leads to impaired angiogenesis in injured mouse cornea.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27(Kip1) and p21(Waf1).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Epigenetic silencing of PEG3 gene expression in human glioma cell lines

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

A role for decorin in the structural organization of periodontal ligament

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4080419

Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation

29 November 2018

1 reference

12 December 2020

Glycosaminoglycans: from "cellular glue" to novel therapeutical agents

1 reference

12 December 2020

An Anti-oncogenic Role for Decorin

1 reference

12 December 2020

Decorin suppresses tumor cell-mediated angiogenesis

1 reference

12 December 2020

Influence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout Mice

1 reference

12 December 2020

10.1016/J.MATBIO.2013.12.011

Identifiers

DOI

1 reference

release_7734yeiqcngyta763lzzu5n3rq

Fatcat ID

0 references

1 reference

1 reference

1 reference