SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1 (Q24321934)

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G D Gish

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G Mbamalu

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N N Iscove

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T Pawson

Journal of Biological Chemistry

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language of work or name

English

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publication date

31 October 1997

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published in

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volume

272

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issue

44

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page(s)

27804-11

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cites work

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A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase

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Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

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The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

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SH2 domain specificity and activity modified by a single residue

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Protein modules and signalling networks

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Requirement for the adapter protein GRB2 in EGF receptor endocytosis

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Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

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Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase

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A potential SH3 domain-binding site in the Crk SH2 domain

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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

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c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3

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7 January 2021

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

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Modular binding domains in signal transduction proteins

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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7 January 2021