MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines (Q24320171)

peptidyl-serine phosphorylation

GOA release 2020-03-11

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GOA release 2020-03-11

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Carol A Chrestensen

1

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Jacquelyn K Shuman

2

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Andrew Eschenroeder

3

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Mark Worthington

4

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Hermann Gram

5

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Thomas W Sturgill

Journal of Biological Chemistry

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language of work or name

English

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publication date

16 February 2007

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published in

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volume

282

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issue

7

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page(s)

4243-52

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cites work

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Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development.

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Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages

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The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1

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Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

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Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1

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Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

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Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.

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Focus on breast cancer

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An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation

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PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

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CSF-1 activates MAPK-dependent and p53-independent pathways to induce growth arrest of hormone-dependent human breast cancer cells

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The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells

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Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases

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The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

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Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling

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MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

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eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

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FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

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MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

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Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

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Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

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Characterization of new estrogen receptor destabilizing compounds: effects on estrogen-sensitive and tamoxifen-resistant breast cancer

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The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

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Mnk is a negative regulator of cap-dependent translation in Aplysia neurons.

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Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

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Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

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The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

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Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

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Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

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Hyperexpression of mitogen-activated protein kinase in human breast cancer

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Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation

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