The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction (Q24319109)

GOA release 2020-03-11

tyrosine kinase 2

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protein tyrosine kinase activity

GOA release 2020-03-11

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GOA release 2020-03-11

J Briscoe

2

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author name string

M Müller

1

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C Laxton

3

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D Guschin

4

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A Ziemiecki

5

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O Silvennoinen

6

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A G Harpur

7

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G Barbieri

8

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B A Witthuhn

9

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C Schindler

Interferons and their actions

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language of work or name

English

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publication date

11 November 1993

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published in

Nature

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volume

366

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issue

6451

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page(s)

129-35

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cites work

1 reference

7 January 2021

Early events in signalling by interferons.

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7 January 2021

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction

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7 January 2021

Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor

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7 January 2021

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

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7 January 2021

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

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7 January 2021

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins

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7 January 2021

Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity

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7 January 2021

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells

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7 January 2021

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro

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7 January 2021

Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

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7 January 2021

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways

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7 January 2021

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

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7 January 2021

The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds

1 reference

7 January 2021

Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds

1 reference

7 January 2021

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3

1 reference

7 January 2021

Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-gamma) activation of the human high-affinity Fc gamma receptor gene: a novel IFN regulatory mechanism

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7 January 2021

Molecular cloning and expression of the human interferon-gamma receptor

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7 January 2021

Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA

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7 January 2021

Structural analysis of the human interferon gamma receptor: a small segment of the intracellular domain is specifically required for class I major histocompatibility complex antigen induction and antiviral activity

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7 January 2021

Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

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7 January 2021

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction

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7 January 2021

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

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7 January 2021

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

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7 January 2021

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

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7 January 2021

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway

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7 January 2021

High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons

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7 January 2021

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either

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7 January 2021

A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter

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7 January 2021

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

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7 January 2021

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

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7 January 2021

Multimolecular associations of the T-cell antigen receptor

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7 January 2021

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

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7 January 2021

The alphas, betas, and kinases of cytokine receptor complexes

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7 January 2021

Tyrosine phosphorylation of DNA binding proteins by multiple cytokines

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7 January 2021

Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei.

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7 January 2021

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

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7 January 2021

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

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7 January 2021

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

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7 January 2021

cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure

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7 January 2021

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

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7 January 2021