WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing (Q24318651)

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19 January 2020

title

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing (English)

1 reference

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Werner syndrome RecQ like helicase

19 January 2020

main subject

1 reference

GOA release 2020-03-11

manganese ion binding

1 reference

GOA release 2020-03-11

author

Lauren Holden

3

1 reference

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19 January 2020

John A. Tainer

9

1 reference

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19 January 2020

author name string

J Jefferson P Perry

1

1 reference

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19 January 2020

Steven M Yannone

2

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19 January 2020

Chiharu Hitomi

4

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19 January 2020

Aroumougame Asaithamby

5

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19 January 2020

Seungil Han

6

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19 January 2020

Priscilla K Cooper

7

1 reference

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19 January 2020

David J Chen

8

1 reference

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19 January 2020

language of work or name

English

0 references

publication date

23 April 2006

1 reference

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Nature Structural & Molecular Biology

19 January 2020

published in

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19 January 2020

volume

13

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19 January 2020

issue

5

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19 January 2020

page(s)

414-422

1 reference

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Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing

19 January 2020

cites work

1 reference

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

31 March 2020

1 reference

Positional cloning of the Werner's syndrome gene

31 March 2020

1 reference

A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.

31 March 2020

1 reference

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

31 March 2020

1 reference

WRN helicase expression in Werner syndrome cell lines

31 March 2020

1 reference

RecQ helicases: caretakers of the genome

31 March 2020

1 reference

The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains

31 March 2020

1 reference

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

31 March 2020

1 reference

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

31 March 2020

1 reference

Werner syndrome protein contains three structure-specific DNA binding domains

31 March 2020

1 reference

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

31 March 2020

1 reference

The Werner syndrome protein at the crossroads of DNA repair and apoptosis

31 March 2020

1 reference

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

31 March 2020

1 reference

WRN interacts physically and functionally with the recombination mediator protein RAD52

31 March 2020

1 reference

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

31 March 2020

1 reference

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

31 March 2020

1 reference

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

31 March 2020

1 reference

Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein

31 March 2020

1 reference

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

31 March 2020

1 reference

Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1

31 March 2020

1 reference

Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

31 March 2020

1 reference

Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

31 March 2020

1 reference

Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment

31 March 2020

1 reference

Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

31 March 2020

1 reference

Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions

31 March 2020

1 reference

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

31 March 2020

1 reference

Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius

31 March 2020

1 reference

The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.

31 March 2020

1 reference

High-resolution structure of the E.coli RecQ helicase catalytic core

31 March 2020

1 reference

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

31 March 2020

1 reference

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

31 March 2020

1 reference

Rejoining of DNA by the RAG1 and RAG2 proteins

31 March 2020

1 reference

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

31 March 2020

1 reference

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

31 March 2020

1 reference

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

31 March 2020

1 reference

Accumulation of Werner protein at DNA double-strand breaks in human cells

31 March 2020

1 reference

Werner syndrome protein--unwinding function to explain disease

31 March 2020

1 reference

The Werner syndrome protein has separable recombination and survival functions

31 March 2020

1 reference

An open and closed case for all polymerases.

31 March 2020

1 reference

Characterization of the human and mouse WRN 3'-->5' exonuclease

31 March 2020

1 reference

Oligomeric ring structure of the Bloom's syndrome helicase

31 March 2020

1 reference

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

31 March 2020

1 reference

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

31 March 2020

1 reference

Structure and function of the double-strand break repair machinery.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB1088

2 references

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

19 January 2020

1007138952

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017