Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A (Q24318410)

regulation of mitotic spindle organization

GOA release 2020-03-11

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TPX2, microtubule-associated

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Anthony A Hyman

2

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author name string

Alexander W Bird

series ordinal

1

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language of work or name

English

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publication date

28 July 2008

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number of pages

12

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

inferred from page(s)

published in

Journal of Cell Biology

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volume

182

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issue

2

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page(s)

289-300

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cites work

1 reference

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HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.

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Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit

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Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis

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Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

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Human TPX2 is required for targeting Aurora-A kinase to the spindle

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Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains

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Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

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30 May 2018

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Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity

21 January 2018

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Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells

21 January 2018

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An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

21 January 2018

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Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly

21 January 2018

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An improved recombineering approach by adding RecA to lambda Red recombination

21 January 2018

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HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

21 January 2018

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The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5

21 January 2018

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12 December 2020

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

1 reference

12 December 2020

Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation

1 reference

12 December 2020

Regulation ofXenopusAurora A Activation by TPX2

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200802005

1 reference

1 reference

1 reference

PubMed publication ID

18663142

1 reference