Cardiac regulation by phosphoinositide 3-kinases and PTEN (Q24317248)

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Europe PubMed Central

title

Cardiac regulation by phosphoinositide 3-kinases and PTEN (English)

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main subject

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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

GOA release 2020-03-11

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negative regulation of cardiac muscle contraction

GOA release 2020-03-11

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Pathways for phosphoinositide synthesis

GOA release 2020-03-11

Josef M Penninger

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author name string

Gavin Y Oudit

series ordinal

1

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language of work or name

English

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publication date

1 May 2009

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published in

Cardiovascular Research

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volume

82

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issue

2

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page(s)

250-60

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cites work

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Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

21 January 2018

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The phosphoinositide (PI) 3-kinase family

21 January 2018

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Phosphoinositide 3-kinase signalling--which way to target?

21 January 2018

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PTEN and myotubularin: novel phosphoinositide phosphatases

21 January 2018

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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

21 January 2018

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

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The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

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Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats

21 January 2018

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Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

21 January 2018

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Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2 ) channels

21 January 2018

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Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway

21 January 2018

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Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells

21 January 2018

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Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

21 January 2018

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Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

21 January 2018

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Analysis of class I phosphoinositide 3-kinase autophosphorylation sites by mass spectrometry

21 January 2018

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PTEN: The down side of PI 3-kinase signalling.

21 January 2018

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Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

21 January 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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Membrane-binding and activation mechanism of PTEN.

21 January 2018

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The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

21 January 2018

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Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate

21 January 2018

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The nuclear affairs of PTEN.

21 January 2018

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Reversible inactivation of the tumor suppressor PTEN by H2O2

21 January 2018

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

21 January 2018

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Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

21 January 2018

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

21 January 2018

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Structure, regulation and function of PKB/AKT--a major therapeutic target

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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PKB binding proteins. Getting in on the Akt.

21 January 2018

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The phosphoinositide 3-kinase pathway

21 January 2018

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GSK-3: tricks of the trade for a multi-tasking kinase

21 January 2018

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Akt2 regulates cardiac metabolism and cardiomyocyte survival

21 January 2018

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Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression

21 January 2018

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Akt/protein kinase B promotes organ growth in transgenic mice

21 January 2018

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

21 January 2018

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Transcriptional effects of chronic Akt activation in the heart.

21 January 2018

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Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

21 January 2018

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Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.

21 January 2018

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Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts

21 January 2018

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Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload

21 January 2018

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Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

21 January 2018

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Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter

21 January 2018

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TOR, a central controller of cell growth

21 January 2018

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Ribosomal S6 kinase signaling and the control of translation

21 January 2018

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Rapamycin attenuates load-induced cardiac hypertrophy in mice

21 January 2018

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

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Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

21 January 2018

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The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

21 January 2018

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Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway

21 January 2018

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Physiological functions of Pten in mouse tissues

21 January 2018

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

21 January 2018

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Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

21 January 2018

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

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Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes

21 January 2018

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Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy

21 January 2018

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

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Role of PI3 kinase gamma in excitation-contraction coupling and heart disease

21 January 2018

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cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

21 January 2018

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Phospholamban: a crucial regulator of cardiac contractility

21 January 2018

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PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes

21 January 2018

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Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation

21 January 2018

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Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility

21 January 2018

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Seven-transmembrane-spanning receptors and heart function

21 January 2018

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Temporally controlled overexpression of cardiac-specific PI3Kalpha induces enhanced myocardial contractility--a new transgenic model

21 January 2018

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Insulin-like growth factor-1 exerts Ca2 -dependent positive inotropic effects in failing human myocardium

21 January 2018

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Insulin-Like Growth Factor-1 and PTEN Deletion Enhance Cardiac L-Type Ca 2 Currents via Increased PI3Kα/PKB Signaling

21 January 2018

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Protein kinase B phosphorylates AHNAK and regulates its subcellular localization

21 January 2018

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The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2 channels and the actin-based cytoskeleton

21 January 2018

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Signaling Mechanisms That Mediate Nitric Oxide Production Induced by Acetylcholine Exposure and Withdrawal in Cat Atrial Myocytes

21 January 2018

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Normal function of HERG K channels expressed in HEK293 cells requires basal protein kinase B activity.

21 January 2018

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Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

21 January 2018

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A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

21 January 2018

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Phosphatases in cell-matrix adhesion and migration

21 January 2018

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Ras, Akt, and mechanotransduction in the cardiac myocyte

21 January 2018

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Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism

21 January 2018

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Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

21 January 2018

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Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway

21 January 2018

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Cell signaling by receptor tyrosine kinases

21 January 2018

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Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation

21 January 2018

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Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

21 January 2018

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Preconditioning the Myocardium: From Cellular Physiology to Clinical Cardiology

21 January 2018

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Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning

21 January 2018

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PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning

21 January 2018

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Second window of protection following myocardial preconditioning: an essential role for PI3 kinase and p70S6 kinase

21 January 2018

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Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective

21 January 2018

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Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1

21 January 2018

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Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway.

21 January 2018

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Protective effects of erythropoietin in cardiac ischemia: from bench to bedside

21 January 2018

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PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning

21 January 2018

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Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA.

21 January 2018

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Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway

21 January 2018

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

21 January 2018

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Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth

21 January 2018

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7 January 2021

Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency

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7 January 2021

Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery

1 reference

7 January 2021

Preconditioning: is the Akt-ion in the PI3K pathway?

1 reference

7 January 2021

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

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7 January 2021

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

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7 January 2021

Molecular mechanisms of contraction-regulated cardiac glucose transport.

1 reference

7 January 2021

Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

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7 January 2021

PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects

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7 January 2021

Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase

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7 January 2021

Competitive displacement of phosphoinositide 3-kinase from β-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling

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7 January 2021

Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors

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7 January 2021

Effects of Akt on cardiac myocytes: location counts

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7 January 2021

Akt1 is required for physiological cardiac growth

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7 January 2021

Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure

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7 January 2021

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

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7 January 2021