MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells (Q24316376)

Polyhomeotic 1

1 reference

Polyhomeotic 2

1 reference

Mitogen-activated protein kinase 14

1 reference

MAP kinase-activated protein kinase 2

1 reference

9

Matthias Gaestel

0 references

Alexey Kotlyarov

7

Alexey Kotlyarov

0 references

Haruhiko Koseki

Haruhiko Koseki

6

0 references

Jessica Schwermann

1

Jessica Schwermann

0 references

Stefanie Schumacher

4

Stefanie Schumacher

0 references

author name string

Chozhavendan Rathinam

2

0 references

Maria Schubert

3

0 references

Fatih Noyan

5

0 references

Christoph Klein

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

8

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language of work or name

English

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publication date

20 May 2009

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published in

The EMBO Journal

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volume

28

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issue

10

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page(s)

1392-406

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cites work

1 reference

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Regulation of the MEF2 family of transcription factors by p38

19 March 2017

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Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

19 March 2017

1 reference

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A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

19 March 2017

1 reference

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

19 March 2017

1 reference

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Molecular basis of MAPK-activated protein kinase 2:p38 assembly

19 March 2017

1 reference

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Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes

19 March 2017

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The many faces of SAM

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MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

19 March 2017

1 reference

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Scaffolding by ERK3 regulates MK5 in development

19 March 2017

1 reference

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

19 March 2017

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

19 March 2017

1 reference

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Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice

19 March 2017

1 reference

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The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides

19 March 2017

1 reference

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

19 March 2017

1 reference

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FRET-based detection of different conformations of MK2.

19 March 2017

1 reference

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Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

19 March 2017

1 reference

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

19 March 2017

1 reference

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Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

19 March 2017

1 reference

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

19 March 2017

1 reference

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

19 March 2017

1 reference

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Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif

19 March 2017

1 reference

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

19 March 2017

1 reference

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

7 April 2017

1 reference

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

7 April 2017

1 reference

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

7 April 2017

1 reference

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

7 April 2017

1 reference

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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

7 April 2017

1 reference

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Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective

7 April 2017

1 reference

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

27 September 2017

1 reference

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The hematopoietic stem cell in its place

27 September 2017

1 reference

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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

MAPKAP kinases - MKs - two's company, three's a crowd

27 September 2017

1 reference

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Hematopoietic stem cells and their niche.

27 September 2017

1 reference

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Division of labor in polycomb group repression

27 September 2017

1 reference

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Stem cells and cancer; the polycomb connection

27 September 2017

1 reference

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Polycomb complexes and silencing mechanisms.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

Map kinase signaling pathways and hematologic malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

Distinct cellular functions of MK2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

Smad7 promotes self-renewal of hematopoietic stem cells

30 May 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

Catalysis and function of the p38 alpha.MK2a signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

The Stress-Activated Hog1 Kinase Is a Selective Transcriptional Elongation Factor for Genes Responding to Osmotic Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.100

Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688528

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

29 November 2018

1 reference

12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

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12 December 2020

Production of monoclonal antibodies against mammalian Ring1B proteins

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12 December 2020

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

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12 December 2020

Activated signal transduction kinases frequently occupy target genes

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12 December 2020

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

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12 December 2020

The function of the NC1 domains in type IV collagen

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https://api.crossref.org/works/10.1038/EMBOJ.2009.100

7 January 2021