The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells (Q24314491)

positive regulation of epithelial cell proliferation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1 reference

18

Hans Clevers

Hans

Clevers

1 reference

20 April 2024

13

Maaike van den Born

Maaike

van den Born

1 reference

20 April 2024

1

Marc van de Wetering

Marc

van de Wetering

1 reference

20 April 2024

4

Wim de Lau

Wim

de Lau

1 reference

20 April 2024

Damien Coudreuse

9

Damien

Coudreuse

1 reference

20 April 2024

Elena Sancho

2

Elena

Sancho

1 reference

20 April 2024

Eduard Batlle

8

Eduard

Batlle

1 reference

20 April 2024

Adam Hurlstone

6

Adam

Hurlstone

1 reference

20 April 2024

Martin Eilers

16

Martin

Eilers

1 reference

20 April 2024

Rene Medema

17

Rene

Medema

1 reference

20 April 2024

3

Cornelis

Verweij

Cornelis Verweij

1 reference

20 April 2024

Irma Oving

5

Irma

Oving

1 reference

20 April 2024

Karin van der Horn

7

Karin

van der Horn

1 reference

20 April 2024

Anna Pavlina Haramis

10

Anna Pavlina

Haramis

1 reference

20 April 2024

Menno Tjon-Pon-Fong

11

Menno

Tjon-Pon-Fong

1 reference

20 April 2024

Petra Moerer

12

Petra

Moerer

1 reference

20 April 2024

Gwen Soete

14

Gwen

Soete

1 reference

20 April 2024

Steven Pals

15

Steven

Pals

1 reference

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium

20 April 2024

language of work or name

English

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publication date

18 October 2002

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published in

Cell

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volume

111

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issue

2

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page(s)

241-50

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cites work

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

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Linking colorectal cancer to Wnt signaling

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Expression of c-myc in non-malignant and pre-malignant gastrointestinal disorders

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Role of p27(Kip1) in human intestinal cell differentiation

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Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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The Myc/Max/Mad network and the transcriptional control of cell behavior

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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Identification of c-MYC as a target of the APC pathway

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

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Lessons from hereditary colorectal cancer

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Distinct beta-catenins mediate adhesion and signalling functions in C. elegans

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

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Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate

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Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers

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XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer

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Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice

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APC mutations occur early during colorectal tumorigenesis

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p27(Kip1) is an inducer of intestinal epithelial cell differentiation

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Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

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CDK inhibitors: positive and negative regulators of G1-phase progression

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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Repression of p15INK4b expression by Myc through association with Miz-1

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

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Wnt signaling controls the phosphorylation status of beta-catenin.

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Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

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p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step

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Coordinating cell proliferation and differentiation

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