Identification of STAT3 as a specific substrate of breast tumor kinase (Q24311267)

tyrosine phosphorylation of STAT protein

GOA release 2020-03-11

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GOA release 2020-03-11

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L Liu

1

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Y Gao

2

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H Qiu

3

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W T Miller

4

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V Poli

5

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N C Reich

Functional roles of STAT family proteins: lessons from knockout mice

6

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language of work or name

English

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publication date

10 August 2006

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published in

Oncogene

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volume

25

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issue

35

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page(s)

4904-12

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cites work

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STAT2 nuclear trafficking

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BRK tyrosine kinase expression in a high proportion of human breast carcinomas

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Stat proteins and oncogenesis

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Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

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Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.

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Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.

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STATs and Gene Regulation

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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Introduction: STATs as essential intracellular mediators of cytokine responses

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Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells

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Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

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Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma

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A new protein containing an SH2 domain that inhibits JAK kinases

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Rac1 mediates STAT3 activation by autocrine IL-6

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Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

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The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

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Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation

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The Stat family in cytokine signaling

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Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

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Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

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Characterization of the 5'-flanking region of the human PTK6 gene

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An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

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Stats: transcriptional control and biological impact

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STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

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Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

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STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif

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Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk

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A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Structure and function of a new STAT-induced STAT inhibitor

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

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Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

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ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

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Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

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Role of the Brk SH3 domain in substrate recognition

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Interaction between Brk kinase and insulin receptor substrate-4.

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

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Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine Kinases

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A family of cytokine-inducible inhibitors of signalling

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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

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Genes involved in tumor invasion and metastasis are differentially modulated by estradiol and progestin in human breast-cancer cells

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

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