ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth (Q24310305)

neuron projection morphogenesis

GOA release 2020-03-11

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GOA release 2020-03-11

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Malcolm Ward

8

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Declan McLoughlin

object named as

Declan M McLoughlin

12

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Christopher Shaw

object named as

Christopher E Shaw

11

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P Nigel Leigh

10

object named as

P Nigel Leigh

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author name string

Elizabeth L Tudor

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Michael S Perkinton

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Anja Schmidt

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Steven Ackerley

4

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Janet Brownlees

5

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Nicholas J O Jacobsen

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Helen L Byers

7

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Alan Hall

9

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Christopher C J Miller

Journal of Biological Chemistry

13

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language of work or name

English

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publication date

14 October 2005

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published in

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volume

280

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issue

41

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page(s)

34735-40

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cites work

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The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

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p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

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Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood

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Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse

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Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

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Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

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Rho GTPases in growth cone guidance

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Rac proteins and the control of axon development

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The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

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Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression.

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The role of Rho GTPases and associated kinases in regulating neurite outgrowth

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The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

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Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo

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Rho GTPases in cell biology

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The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

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Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord

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Differential neurochemical properties of central serotonergic transmission in Roman high- and low-avoidance rats

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Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

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The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

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The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling

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The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

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GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation

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A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

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The genetics of motor neuron diseases

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The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

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Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.

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Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene

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A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

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Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport

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ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

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Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

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Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

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Rac1 mediates collapsin-1-induced growth cone collapse

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Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1

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Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology.

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Identifiers

DOI

10.1074/JBC.M506216200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16049005

1 reference

Consolidated OpenCitations Corpus – April 2017