P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration (Q24310060)

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31 December 2019

title

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration (English)

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31 December 2019

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Ivette Hernández-Negrete

1

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31 December 2019

J. Silvio Gutkind

7

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31 December 2019

Jose Vazquez-prado

8

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31 December 2019

author name string

Jorge Carretero-Ortega

2

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31 December 2019

Hans Rosenfeldt

3

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31 December 2019

Ricardo Hernández-García

4

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31 December 2019

J Victor Calderón-Salinas

5

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31 December 2019

Guadalupe Reyes-Cruz

6

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31 December 2019

language of work or name

English

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publication date

12 June 2007

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Journal of Biological Chemistry

31 December 2019

published in

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31 December 2019

volume

282

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31 December 2019

issue

32

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31 December 2019

page(s)

23708-23715

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Growing roles for the mTOR pathway

31 December 2019

cites work

1 reference

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7 January 2021

TOR signaling in growth and metabolism

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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7 January 2021

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

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7 January 2021

P-Rex1 regulates neutrophil function

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7 January 2021

P-Rex2, a new guanine-nucleotide exchange factor for Rac

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7 January 2021

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

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7 January 2021

Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.

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The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

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The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

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7 January 2021

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

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7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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7 January 2021

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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7 January 2021

mTOR and cancer: insights into a complex relationship

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7 January 2021

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

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7 January 2021

TOR2 is required for organization of the actin cytoskeleton in yeast

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7 January 2021

Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin

1 reference

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7 January 2021

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

1 reference

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7 January 2021

Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.

1 reference

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7 January 2021

Molecular organization of target of rapamycin complex 2.

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7 January 2021

Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers

1 reference

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7 January 2021

Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity

1 reference

https://api.crossref.org/works/10.1074/JBC.M703771200

7 January 2021

Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region

1 reference

https://api.crossref.org/works/10.1074/JBC.M703771200

7 January 2021

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium

1 reference

https://api.crossref.org/works/10.1074/JBC.M703771200

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1074/JBC.M703771200

7 January 2021

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M703771200

7 January 2021

Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration

1 reference

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7 January 2021

Identifiers

DOI

10.1074/JBC.M703771200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17565979 AND SRC:MED&resulttype=core&format=json

31 December 2019

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