Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis (Q24308696)

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22 February 2020

title

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis (English)

1 reference

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amyotrophic lateral sclerosis

22 February 2020

main subject

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Sigma non-opioid intracellular receptor 1

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GOA release 2020-03-11

author

Istvan Katona

3

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22 February 2020

author name string

J Prause

1

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22 February 2020

A Goswami

2

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22 February 2020

A Roos

4

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22 February 2020

M Schnizler

5

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22 February 2020

E Bushuven

6

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22 February 2020

A Dreier

7

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22 February 2020

S Buchkremer

8

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22 February 2020

S Johann

9

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22 February 2020

C Beyer

10

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22 February 2020

M Deschauer

11

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22 February 2020

D Troost

12

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22 February 2020

J Weis

13

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22 February 2020

language of work or name

English

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publication date

11 January 2013

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22 February 2020

published in

Human Molecular Genetics

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volume

22

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issue

8

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22 February 2020

page(s)

1581-1600

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Establishment and culture of human skin fibroblasts

22 February 2020

cites work

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Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers

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Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.

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A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis

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Presynaptic terminal loss from alpha-motoneurones following the retrograde axonal transport of diphtheria toxin

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Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2 -ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture

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Low density of sigma1 receptors in early Alzheimer's disease

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Cetuximab induces mitochondrial translocalization of EGFRvIII, but not EGFR: involvement of mitochondria in tumor drug resistance?

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Sigma-1R agonist improves motor function and motoneuron survival in ALS mice

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Novel antipsychotic drugs share high affinity for sigma receptors

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A proposal for the classification of sigma binding sites

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Caffeine-induced calcium release from internal stores in cultured rat sensory neurons.

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Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

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Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction

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Novel splice variants of the amyotrophic lateral sclerosis-associated gene VAPB expressed in human tissues

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Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2 ) signaling and cell survival

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Rethinking ALS: the FUS about TDP-43.

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The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

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The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse

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Calcium signaling and neurodegenerative diseases

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Chaperone networks: tipping the balance in protein folding diseases

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Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons.

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7 January 2021

The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

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7 January 2021

MAM: more than just a housekeeper

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Silencing of sigma-1 receptor induces cell death in human lens cells

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7 January 2021

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

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7 January 2021

Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands

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7 January 2021

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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7 January 2021

Physiological levels of ATP negatively regulate proteasome function.

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7 January 2021

The mitochondrial calcium uniporter is a highly selective ion channel.

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7 January 2021

Protein aggregation and neurodegenerative disease

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7 January 2021

Regulation of cell death: the calcium-apoptosis link

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7 January 2021

Opinion: What is the role of protein aggregation in neurodegeneration?

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7 January 2021

Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis

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7 January 2021

Protein aggregation in motor neurone disorders.

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7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

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7 January 2021

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

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7 January 2021

Purification, molecular cloning, and expression of the mammalian sigma1-binding site

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7 January 2021

Activation of the cell death program by inhibition of proteasome function

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7 January 2021

Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance

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7 January 2021

Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.

1 reference

7 January 2021

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

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7 January 2021

Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis.

1 reference

7 January 2021

The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones

1 reference

7 January 2021

Aspirin induces apoptosis through the inhibition of proteasome function

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7 January 2021

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

1 reference

7 January 2021

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

1 reference

7 January 2021

The ubiquitin-proteasome pathway: on protein death and cell life

1 reference

7 January 2021

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

7 January 2021

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

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7 January 2021

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

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7 January 2021

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

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7 January 2021

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

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7 January 2021

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.

1 reference

7 January 2021

The p.P56S mutation in the VAPB gene is not due to a single founder: the first European case

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7 January 2021

Increase in presynaptic territory of C-terminals on lumbar motoneurons of G93A SOD1 mice during disease progression

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7 January 2021

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

1 reference

7 January 2021

Function of sigma1 receptors in Parkinson's disease

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7 January 2021

Toxic proteins in neurodegenerative disease

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7 January 2021

Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems

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7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

7 January 2021

Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis.

1 reference

7 January 2021

SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations

1 reference

7 January 2021

Regulation mechanisms and signaling pathways of autophagy

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7 January 2021

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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7 January 2021

Sigma Receptor Type 1 Gene Variation in a Group of Polish Patients with Alzheimer’s Disease and Mild Cognitive Impairment

1 reference

7 January 2021

sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion

1 reference

7 January 2021

Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

1 reference

7 January 2021

sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation

1 reference

7 January 2021

Autophagosome formation in mammalian cells

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7 January 2021

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.

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7 January 2021

Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases.

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7 January 2021

Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer's disease

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Imaging of sigma1 receptors in the human brain using PET and [11C]SA4503.

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7 January 2021

Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis

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7 January 2021

Identifiers

DOI

10.1093/HMG/DDT008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23314020 AND SRC:MED&resulttype=core&format=json

22 February 2020

1 reference