Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies (Q24307627)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21700325 AND SRC:MED&resulttype=core&format=json

5 February 2020

title

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies (English)

1 reference

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5 February 2020

main subject

Glucosylceramidase beta

1 reference

positive regulation of proteolysis involved in cellular protein catabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

Glucosidase, beta, acid

1 reference

GOA release 2020-03-11

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1 reference

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6

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5 February 2020

author name string

Joseph R Mazzulli

1

1 reference

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5 February 2020

You-Hai Xu

2

1 reference

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5 February 2020

Ying Sun

3

1 reference

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5 February 2020

Adam L Knight

4

1 reference

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5 February 2020

Pamela J McLean

5

1 reference

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5 February 2020

Ellen Sidransky

7

1 reference

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5 February 2020

Gregory A Grabowski

8

1 reference

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5 February 2020

Dimitri Krainc

9

1 reference

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5 February 2020

language of work or name

English

0 references

publication date

23 June 2011

1 reference

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5 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21700325 AND SRC:MED&resulttype=core&format=json

5 February 2020

volume

146

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5 February 2020

issue

1

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5 February 2020

page(s)

37-52

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Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

5 February 2020

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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7 April 2017

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Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration

27 September 2017

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The risk of Parkinson's disease in type 1 Gaucher disease

27 September 2017

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27 September 2017

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Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence

27 September 2017

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Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.

27 September 2017

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Gaucher disease and parkinsonism

27 September 2017

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Parkinsonism among Gaucher disease carriers

27 September 2017

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

27 September 2017

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Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses

27 September 2017

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The fine structure of the cerebroside occurring in Gaucher's disease

27 September 2017

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

27 September 2017

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Occurrence of Parkinson's syndrome in type I Gaucher disease

27 September 2017

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Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models

27 September 2017

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Viable mouse models of acid beta-glucosidase deficiency: the defect in Gaucher disease

30 May 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

30 May 2018

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Biosynthesis of the lysosomal enzyme glucocerebrosidase

30 May 2018

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Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

30 May 2018

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GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

29 November 2018

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Glucocerebrosidase mutations are an important risk factor for Lewy body disorders

29 November 2018

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Gaucher disease mouse models: point mutations at the acid beta-glucosidase locus combined with low-level prosaposin expression lead to disease variants.

29 November 2018

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Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

29 November 2018

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Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

29 November 2018

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29 November 2018

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29 November 2018

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29 November 2018

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29 November 2018

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29 November 2018

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29 November 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

29 November 2018

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Gaucher disease and parkinsonism: a phenotypic and genotypic characterization

29 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21700325

12 December 2020

inferred from PubMed ID database lookup

The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21700325

12 December 2020

inferred from PubMed ID database lookup

Glucocerebrosidase gene mutations in patients with type 2 Gaucher disease

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https://api.crossref.org/works/10.1016/J.CELL.2011.06.001

7 January 2021

Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model

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7 January 2021

Methods to monitor chaperone-mediated autophagy

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7 January 2021

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

1 reference

https://api.crossref.org/works/10.1016/J.CELL.2011.06.001

7 January 2021

Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients.

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https://api.crossref.org/works/10.1016/J.CELL.2011.06.001

7 January 2021

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

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7 January 2021

10.1016/J.CELL.2011.06.001

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21700325 AND SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21700325 AND SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

21700325

2 references