NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity (Q24306480)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832462 AND SRC:MED&resulttype=core&format=json

5 November 2019

title

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity (English)

1 reference

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Nuclear factor kappa B subunit 1

5 November 2019

main subject

cell biology

0 references

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Stephen J Smerdon

7

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5 November 2019

author name string

S Beinke

1

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5 November 2019

J Deka

2

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5 November 2019

V Lang

3

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5 November 2019

M P Belich

4

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5 November 2019

P A Walker

5

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5 November 2019

S Howell

6

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5 November 2019

S J Gamblin

8

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5 November 2019

S C Ley

9

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5 November 2019

language of work or name

English

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publication date

1 July 2003

1 reference

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Molecular and Cellular Biology

5 November 2019

published in

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5 November 2019

volume

23

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5 November 2019

issue

14

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5 November 2019

page(s)

4739-4752

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Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

5 November 2019

cites work

1 reference

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Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

19 March 2017

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NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

19 March 2017

1 reference

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Structure of an IkappaBalpha/NF-kappaB complex

19 March 2017

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19 March 2017

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The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation

19 March 2017

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The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation

19 March 2017

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

19 March 2017

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betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

19 March 2017

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Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis

19 March 2017

1 reference

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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

19 March 2017

1 reference

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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

19 March 2017

1 reference

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

19 March 2017

1 reference

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

19 March 2017

1 reference

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

19 March 2017

1 reference

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Expression cDNA cloning of a serine kinase transforming gene

19 March 2017

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

19 March 2017

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

7 April 2017

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Structure, regulation and function of NF-kappa B

7 April 2017

1 reference

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The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis

7 April 2017

1 reference

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

27 September 2017

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27 September 2017

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Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

27 September 2017

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27 September 2017

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Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion.

27 September 2017

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Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

27 September 2017

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Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

27 September 2017

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27 September 2017

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27 September 2017

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The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A.

27 September 2017

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30 May 2018

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29 November 2018

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Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50

29 November 2018

1 reference

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Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

29 November 2018

1 reference

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10.1128/MCB.23.14.4739-4752.2003

29 November 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832462 AND SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12832462 AND SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

12832462

2 references