p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity (Q24306090)

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21 February 2020

title

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity (English)

1 reference

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Eukaryotic translation initiation factor 2 alpha kinase 2

21 February 2020

main subject

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Eukaryotic translation initiation factor 2 alpha kinase 4

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Eukaryotic translation initiation factor 2 alpha kinase 3

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cellular response to cold

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DnaJ heat shock protein family (Hsp40) member C3

1 reference

Eukaryotic translation initiation factor 2 alpha kinase 4

1 reference

author

Amandine Bastide

3

1 reference

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21 February 2020

John Knight

4

1 reference

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21 February 2020

Christopher Mark Smales

6

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21 February 2020

author name string

Anne Roobol

1

1 reference

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21 February 2020

Jo Roobol

2

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21 February 2020

Anne E Willis

5

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21 February 2020

language of work or name

English

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publication date

1 January 2015

1 reference

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21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329545 AND SRC:MED&resulttype=core&format=json

21 February 2020

volume

465

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21 February 2020

issue

2

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21 February 2020

page(s)

213-225

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 February 2020

cites work

1 reference

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

20 April 2017

1 reference

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

20 April 2017

1 reference

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

20 April 2017

1 reference

The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity

20 April 2017

1 reference

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

20 April 2017

1 reference

The Crystal Structure of the Human Co-Chaperone P58IPK

20 April 2017

1 reference

Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

20 April 2017

1 reference

The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity

20 April 2017

1 reference

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

20 April 2017

1 reference

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

20 April 2017

2 references

20 April 2017

New modes of translational control in development, behavior, and disease

20 April 2017

1 reference

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

21 January 2018

1 reference

A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells

21 January 2018

1 reference

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.

21 January 2018

1 reference

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

21 January 2018

1 reference

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

21 January 2018

1 reference

Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor

21 January 2018

1 reference

P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection.

21 January 2018

1 reference

Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.

21 January 2018

1 reference

Loss of mitofusin 2 promotes endoplasmic reticulum stress

21 January 2018

1 reference

Structural insight into the protective role of P58(IPK) during unfolded protein response

21 January 2018

1 reference

Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function

21 January 2018

1 reference

The J-domain family and the recruitment of chaperone power

21 January 2018

1 reference

The role of p58IPK in protecting the stressed endoplasmic reticulum

21 January 2018

1 reference

eIF2alpha phosphorylation, stress perception, and the shutdown of global protein synthesis in cultured CHO cells

21 January 2018

1 reference

On the effect of transient expression of mutated eIF2alpha and eIF4E eukaryotic translation initiation factors on reporter gene expression in mammalian cells upon cold-shock

21 January 2018

1 reference

Post-translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells.

21 January 2018

1 reference

The cold-shock response in cultured mammalian cells: harnessing the response for the improvement of recombinant protein production.

21 January 2018

1 reference

Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems.

21 January 2018

1 reference

Metabolic rates, growth phase, and mRNA levels influence cell-specific antibody production levels from in vitro-cultured mammalian cells at sub-physiological temperatures.

21 January 2018

1 reference

The architecture of eukaryotic translation

21 January 2018

1 reference

ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53.

21 January 2018

1 reference

Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming

21 January 2018

1 reference

The cold-shock response in mammalian cells: investigating the HeLa cell cold-shock proteome

21 January 2018

1 reference

Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs

21 January 2018

1 reference

A novel and versatile computational tool to model translation.

21 January 2018

1 reference

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

21 January 2018

1 reference

The role of tRNA and ribosome competition in coupling the expression of different mRNAs in Saccharomyces cerevisiae

21 January 2018

1 reference

Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells

21 January 2018

1 reference

Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress

21 January 2018

1 reference

Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation

21 January 2018

1 reference

Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells

21 January 2018

1 reference

Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition

21 January 2018

1 reference

Proteomic profiling of a high-producing Chinese hamster ovary cell culture

21 January 2018

1 reference

Charting the dynamics of translation

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Alternatively folded states of an immunoglobulin

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1042/BJ20140852

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25329545 AND SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017